Evidence map›Paper›PMID 33051295›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

One-dimensional spatial patterning along mitotic chromosomes: A mechanical basis for macroscopic morphogenesis.

Lingluo Chu, Zhangyi Liang, Maria V Mukhina, Jay K Fisher, John W Hutchinson, Nancy E Kleckner

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Mitotic genome folding.The Journal of cell biology · 2025
    Review
  4. Article
  5. Article
  6. Sister chromatids separate during anaphase in a three-stage program as directed by interaxis bridges.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  7. Physical mechanisms of ESCRT-III-driven cell division.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Mitotic chromosomes.Seminars in cell & developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lingluo ChuDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138.ORCID 0000-0002-3082-097X
Zhangyi LiangDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138.
Maria V MukhinaDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138.ORCID 0000-0001-9656-1221
Jay K FisherRedbud Labs, Research Triangle Park, NC 27709.
John W HutchinsonSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.
Nancy E KlecknerDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138; kleckner@fas.harvard.edu.

Funding

MEIOTIC CHROMOSOME SYNAPSIS AND RECOMBINATION IN YEASTR01GM044794 · NIGMS · HARVARD UNIVERSITY · PI KLECKNER, NANCY E · 1990 to 2018
$13.8M
ILLEGITIMATE RECOMBINATION BY DRUG RESISTANCE ELEMENTSR01GM025326 · NIGMS · HARVARD UNIVERSITY · PI KLECKNER, NANCY E · 1985 to 2019
$12.5M
Chromosome organization and function in time and space: meiosis, mitosis and E. coliR35GM136322 · NIGMS · HARVARD UNIVERSITY · PI Nancy E Kleckner · 2020 to 2026
$7.3M
NIGMS NIH HHS R01 GM025326NIGMS NIH HHS R01 GM044794NIGMS NIH HHS R35 GM136322
6 · The paper itself

Abstract

Spatial patterns are ubiquitous in both physical and biological systems. We have recently discovered that mitotic chromosomes sequentially acquire two interesting morphological patterns along their structural axes [L. Chu et al.,

Indexed as

Cell LineChromatidsChromatinChromosomesHumansMitosisMorphogenesisChromatinhelical perversionmitotic chromosomesspatial patterning

Identifiers

PMID33051295
PMCPMC7604413

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.