Evidence map›Paper›PMID 33051294›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Contractile pericytes determine the direction of blood flow at capillary junctions.

Albert L Gonzales, Nicholas R Klug, Arash Moshkforoush, Jane C Lee, Frank K Lee, Bo Shui, Nikolaos M Tsoukias, Michael I Kotlikoff, David Hill-Eubanks, Mark T Nelson

Open access · greenAbstract readVideo-Audio Media
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 224 citations in OpenAlex.

  1. Article
  2. Article
  3. Pericyte KNature cardiovascular research · 2026
    Article
  4. Article
  5. Skin capillary endothelial cells form a network of spatiotemporally conserved CaProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. IPbioRxiv : the preprint server for biology · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Persistent dysmorphology and dysfunction of the brain microvasculature following repeated trauma.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  17. Article
  18. Microvascular architecture and physiological fluctuations constrain the control of cerebral microcirculation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  19. Article
  20. Review

92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Albert L GonzalesDepartment of Pharmacology, University of Vermont, Burlington, VT 05404.
Nicholas R KlugDepartment of Pharmacology, University of Vermont, Burlington, VT 05404.ORCID 0000-0001-7540-0306
Arash MoshkforoushDepartment of Biomedical Engineering, Florida International University, Miami, FL 33199.ORCID 0000-0003-4572-8911
Jane C LeeDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.ORCID 0000-0003-0557-3900
Frank K LeeDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
Bo ShuiDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.ORCID 0000-0001-5744-9886
Nikolaos M TsoukiasDepartment of Biomedical Engineering, Florida International University, Miami, FL 33199.ORCID 0000-0002-5164-9577
Michael I KotlikoffDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
David Hill-EubanksDepartment of Pharmacology, University of Vermont, Burlington, VT 05404.
Mark T NelsonDepartment of Pharmacology, University of Vermont, Burlington, VT 05404; Mark.Nelson@uvm.edu.
Cornell University · USUniversity of Vermont · USFlorida International University · USNational Technical University of Athens · GR

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Marian L Waterman · 1994 to 2026
$57.9M
Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseR35HL140027 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2025
$6.3M
HEMOSTASIS &THROMBOSIS PROGRAM FOR ACADEMIC TRAINEEST32HL007594 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI KELM, ROBERT J · 1985 to 2015
$4.6M
Genetic Resource for Optical SignalingR24HL120847 · NHLBI · CORNELL UNIVERSITY · PI KOTLIKOFF, MICHAEL I. · 2014 to 2018
$3.1M
Ion Channel Dysfunction in Small Vessel Disease of the BrainR01NS110656 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2023
$2.6M
Pericyte Control of Junctional Blood FlowK01HL138215 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI GONZALES, ALBERT LOUIS · 2017 to 2021
$744k
Transitional Segment Hypercontractility in Small Vessel Disease with Intracerebral HemorrhageF32HL152576 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KLUG, NICHOLAS RYAN · 2020 to 2022
$201k
NCI NIH HHS P30 CA062203NHLBI NIH HHS F32 HL152576NHLBI NIH HHS K01 HL138215NHLBI NIH HHS R24 HL120847NHLBI NIH HHS R35 HL140027NHLBI NIH HHS T32 HL007594NINDS NIH HHS R01 NS110656
6 · The paper itself

Abstract

The essential function of the circulatory system is to continuously and efficiently supply the O

Indexed as

Cerebrovascular CirculationMicrocirculationAnimalsArteriolesCalcium ChannelsCapillariesCerebral VeinsMicePericytesCalcium Channelscerebral blood flowfunctional hyperemiapericytes

Identifiers

PMID33051294
PMCPMC7604512
OpenAlexW3091832293

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.