Evidence map›Paper›PMID 33051256›Full record

ArticleDevelopment (Cambridge, England)2020

PLP-1 is essential for germ cell development and germline gene silencing in

Rajaram Vishnupriya, Linitha Thomas, Lamia Wahba, Andrew Fire, Kuppuswamy Subramaniam

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Rajaram VishnupriyaDepartment of Biotechnology, Indian Institute of Technology-Madras, Chennai 600036, India.
Linitha ThomasDepartment of Biological Sciences & Bioengineering, Indian Institute of Technology, Kanpur 208016, India.ORCID 0000-0002-6109-3402
Lamia WahbaDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Andrew FireDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kuppuswamy SubramaniamDepartment of Biotechnology, Indian Institute of Technology-Madras, Chennai 600036, India subbu@iitm.ac.in.ORCID 0000-0002-3191-0109
Indian Institute of Technology Madras · INStanford University · USIndian Institute of Technology Kanpur · IN

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Cellular Response to Genetic ChangeR35GM130366 · NIGMS · STANFORD UNIVERSITY · PI ANDREW Z. FIRE · 2019 to 2026
$4.8M
NIGMS NIH HHS R35 GM130366NIH HHS P40 OD010440
6 · The paper itself

Abstract

The germline genome is guarded against invading foreign genetic elements by small RNA-dependent gene-silencing pathways. Components of these pathways localize to, or form distinct aggregates in the vicinity of, germ granules. These components and their dynamics in and out of granules are currently being intensively studied. Here, we report the identification of PLP-1, a

Indexed as

Gene SilencingAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsDNA-Binding ProteinsGerm CellsMaleCaenorhabditis elegans ProteinsDNA-Binding ProteinsMajor sperm proteinsP granulespiRNApuf-8Pur-alpha

Identifiers

PMID33051256
PMCPMC7710023
OpenAlexW3092525615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.