Evidence map›Paper›PMID 33051250›Full record

ReviewDevelopment (Cambridge, England)2020

Evolution and development of complex eyes: a celebration of diversity.

Kristen M Koenig, Jeffrey M Gross

Open access · bronzeAbstract readReview
In one paragraph

Review in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Dynamic changes in ocular shape during human development and its implications for retina fovea formation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Pooled it
  2. Article
  3. Review
  4. Global challenges for lens and cataract research.Frontiers in ophthalmology · 2026
    Article
  5. Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kristen M KoenigDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA kmkoenig@fas.harvard.edu grossjm@pitt.edu.ORCID 0000-0001-6093-2262
Jeffrey M GrossDepartments of Ophthalmology and Developmental Biology, Louis J. Fox Center for Vision Restoration, The University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA kmkoenig@fas.harvard.edu grossjm@pitt.edu.ORCID 0000-0002-9422-6312
Harvard University · USUniversity of Pittsburgh · US

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Marlene Behrmann · 1989 to 2026
$17.8M
Genetic Regulation of Eye Development in ZebrafishR01EY018005 · NEI · UNIVERSITY OF TEXAS AT AUSTIN · PI GROSS, JEFFREY · 2008 to 2017
$3.3M
Investigating Organ Formation and the Emergence of Complexity in the Visual System Using Comparative Developmental ApproachesDP5OD023111 · OD · HARVARD UNIVERSITY · PI KOENIG, KRISTEN MARIE · 2016 to 2020
$2.1M
DNA Methylation and Hydroxymethylation During Retinal Development and Stem Cell MaintenanceR01EY029031 · NEI · UNIVERSITY OF TEXAS AT AUSTIN · PI GROSS, JEFFREY · 2018 to 2022
$1.9M
NEI NIH HHS P30 EY008098NEI NIH HHS R01 EY018005NEI NIH HHS R01 EY029031NIH HHS DP5 OD023111
6 · The paper itself

Abstract

For centuries, the eye has fascinated scientists and philosophers alike, and as a result the visual system has always been at the forefront of integrating cutting-edge technology in research. We are again at a turning point at which technical advances have expanded the range of organisms we can study developmentally and deepened what we can learn. In this new era, we are finally able to understand eye development in animals across the phylogenetic tree. In this Review, we highlight six areas in comparative visual system development that address questions that are important for understanding the developmental basis of evolutionary change. We focus on the opportunities now available to biologists to study the developmental genetics, cell biology and morphogenesis that underlie the incredible variation of visual organs found across the Metazoa. Although decades of important work focused on gene expression has suggested homologies and potential evolutionary relationships between the eyes of diverse animals, it is time for developmental biologists to move away from this reductive approach. We now have the opportunity to celebrate the differences and diversity in visual organs found across animal development, and to learn what it can teach us about the fundamental principles of biological systems and how they are built.

Indexed as

AnimalsBiological EvolutionMorphogenesisPhylogenyRetinaEvolutionEyeMorphogenesisRetinaVisual system

Identifiers

PMID33051250
PMCPMC7578360
OpenAlexW3091812689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.