ArticleBMJ open2020
Association between hyperemesis gravidarum and psychological symptoms, psychosocial outcomes and infant bonding: a two-point prospective case-control multicentre survey study in an inner city setting.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Features of nausea and vomiting in pregnancy as predictive factors of post-partum depression: a systematic review.BMC pregnancy and childbirth · 2025Pooled it
- Prevalence and determinants of hyperemesis gravidarum among pregnant women in Ethiopia: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Construction of a Risk Identification Model Based on Electrolytes and Related Factors for Nausea and Vomiting in Pregnancy: A Secondary Analysis of Clinical Trial Data.International journal of women's health · 2026Article
- Association Between Depression and the Risk of Hyperemesis Gravidarum: A Systematic Review and Meta-Analysis.Neuropsychiatric disease and treatment · 2026Review
- Building a Machine Learning Model to Predict Postpartum Depression from Electronic Health Records in a Tertiary Care Setting.Journal of clinical medicine · 2025Article
- Social and obstetric risk factors of antenatal depression: A cross-sectional study in China.World journal of psychiatry · 2025Article
- Electroacupuncture and vagus nerve stimulation are emerging therapies for hyperemesis gravidarum management.Frontiers in neurology · 2025Review
- The clinical significance of D-dimer concentrations predicting the risk of venous thromboembolism in patients with hyperemesis gravidarum.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Diagnosis and treatment of hyperemesis gravidarum.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024Review
- Maternal Antibiotic Exposure and the Risk of Developing Antenatal Depressive Symptoms.Journal of clinical medicine · 2024Article
- Re-examining the adaptive function of nausea and vomiting in pregnancy.Evolution, medicine, and public health · 2024Article
- Effect of nausea and vomiting during pregnancy on mother-to-infant bonding and the mediation effect of postpartum depression: the Japan Environment and Children's Study.BMC pregnancy and childbirth · 2023Article
- Retrospective Analysis of Hyperemesis Gravidarum and Its Psychological Impact during Hospital Admission.Journal of obstetrics and gynaecology of India · 2023Article
- Systematic evidence map of evidence addressing the top 10 priority research questions for hyperemesis gravidarum.BMJ open · 2022Article
- Lifetime prevalence and correlates of perinatal depression in a case-cohort study of depression.BMJ open · 2022Article
- Article
- Emerging Progress in Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum: Challenges and Opportunities.Frontiers in medicine · 2021Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess if there is any association between hyperemesis gravidarum (HG), psychological morbidity and infant bonding and to quantify any psychosocial consequences of HG.
designTwo-point prospective case-control, multicentre survey study with antenatal and postnatal data collection.
settingThree London hospitals.
participantsPregnant women at ≤12 completed weeks gestation recruited consecutively over 2 years. Women with HG were recruited at the time of admission; controls recruited from a low risk antenatal clinic. 106 women were recruited to the case group and 108 to the control. Response rates at antenatal data collection were 87% and 85% in the case and control groups, respectively. Postnatally, the response rate was 90% in both groups. PRIMARY AND SECONDARY OUTCOME MEASURES: Primary outcomes were psychological morbidity in the antenatal and postnatal periods, infant bonding in the postnatal period and psychosocial implications of HG. Secondary outcomes were the effects of severity and longevity of HG and assessment of correlation between Edinburgh Postnatal Depression Scale scores and maternal-to-infant bonding scores.
resultsAntenatally, 49% of cases had probable depression compared with 6% of controls (OR 14.4 (5.29 to 39.44)). Postnatally, 29% of cases had probable depression versus 7% of controls (OR 5.2 (1.65 to 17.21)). There was no direct association between HG and infant bonding. 53% of women in the HG group reported needing four or more weeks of sick leave compared with 2% in the control group (OR 60.5 (95% CI 8.4 to 2535.6)).
conclusionsLong-lasting psychological morbidity associated with HG was evident. Significantly more women in the case group sought help for mental health symptoms in the antenatal period, however very few were diagnosed with or treated for depression in pregnancy or referred to specialist perinatal mental health services. HG did not directly affect infant bonding. Women in the case group required long periods off work, highlighting the socioeconomic impact of HG.
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