Evidence map›Paper›PMID 33051202›Full record

ArticleThe Journal of biological chemistry2020

Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors.

Sai Shashank Chavali, Sachitanand M Mali, Jermaine L Jenkins, Rudi Fasan, Joseph E Wedekind

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Inferring phase transitions and critical exponents from limited observations with thermodynamic maps.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Review
  6. Article
  7. Review
  8. Small Molecules Targeting Viral RNA.International journal of molecular sciences · 2023
    Review
  9. Article
  10. Review
  11. Article
  12. RNA-Binding Macrocyclic Peptides.Frontiers in molecular biosciences · 2022
    Review
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sai Shashank ChavaliDepartment of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Sachitanand M MaliDepartment of Chemistry, University of Rochester, Rochester, New York, USA.
Jermaine L JenkinsDepartment of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Rudi FasanDepartment of Chemistry, University of Rochester, Rochester, New York, USA.
Joseph E WedekindDepartment of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. Electronic address: joseph.wedekind@rochester.edu.
University of Rochester · US

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
Macrocyclic Peptide Modulators of Protein FunctionR01GM134076 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI FASAN, RUDI · 2019 to 2022
$1.2M
Cyclic Peptide Inhibitors of HIV-1 ProliferationR01AI150463 · NIAID · UNIVERSITY OF ROCHESTER · PI WEDEKIND, JOSEPH E · 2019 to 2020
$774k
Matrix-Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF/TOF) Mass SpectrometerS10OD030302 · OD · UNIVERSITY OF ROCHESTER · PI NILSSON, BRADLEY L. · 2021 to 2021
$304k
NIAID NIH HHS R01 AI150463NIGMS NIH HHS P41 GM103393NIGMS NIH HHS R01 GM134076NIH HHS S10 OD030302
6 · The paper itself

Abstract

RNA-protein interfaces control key replication events during the HIV-1 life cycle. The viral

Indexed as

Amino Acid SequenceArginineCrystallography, X-RayDrug DesignHIV-1HIV Long Terminal RepeatHumansKineticsMolecular Dynamics SimulationMutagenesis, Site-DirectedNucleic Acid ConformationPeptides, CyclicProtein BindingRNA, ViralTATA-Box Binding ProteinThermodynamicsArgininePeptides, CyclicRNA, ViralTATA-Box Binding ProteinTBP protein, humanarginine-rich domaincyclic peptidecyclic peptide inhibitordrug discoveryHIV TARHIV Tathuman immunodeficiency virus (HIV)isothermal titration calorimetryisothermal titration calorimetry (ITC)peptide chemical synthesisRNA-binding proteinRNA-protein interactionRNA-protein interactionsRNA structuresurface plasmon resonancesurface plasmon resonance (SPR)X-ray crystallography

Identifiers

PMID33051202
PMCPMC7864049
OpenAlexW3092492541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.