Evidence map›Paper›PMID 33050999›Full record

ArticleeLife2020

Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells.

Neel S Singhal, Meirong Bai, Evan M Lee, Shuo Luo, Kayleigh R Cook, Dengke K Ma

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Neel S Singhal *Department of Neurology, University of California-San Francisco, San Francisco, United States.ORCID 0000-0003-1605-4444
Meirong Bai *Cardiovascular Research Institute, University of California-San Francisco, San Francisco, United States.ORCID 0000-0002-5919-7464
Evan M LeeCardiovascular Research Institute, University of California-San Francisco, San Francisco, United States.
Shuo LuoCardiovascular Research Institute, University of California-San Francisco, San Francisco, United States.
Kayleigh R CookCardiovascular Research Institute, University of California-San Francisco, San Francisco, United States.
Dengke K MaCardiovascular Research Institute, University of California-San Francisco, San Francisco, United States.ORCID 0000-0002-5619-7485
University of California, San Francisco · US

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kate Taylor Shumate · 1999 to 2026
$209.7M
Dissecting a Novel Genetic Pathway for Fatty Acid Desaturation and Temperature AdaptationR01GM117461 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MA, DENGKE · 2016 to 2020
$1.6M
American Heart Association 18CDA34030443American Heart Association 19POST34381071NCI NIH HHS P30 CA082103NIGMS NIH HHS R01 GM117461
6 · The paper itself

Abstract

Many organisms in nature have evolved mechanisms to tolerate severe hypoxia or ischemia, including the hibernation-capable Arctic ground squirrel (AGS). Although hypoxic or ischemia tolerance in AGS involves physiological adaptations, little is known about the critical cellular mechanisms underlying intrinsic AGS cell resilience to metabolic stress. Through cell survival-based cDNA expression screens in neural progenitor cells, we identify a genetic variant of AGS

Indexed as

Genetic VariationSciuridaeAnimalsCells, CulturedCytoprotectionGene Expression Regulation, EnzymologicHibernationMitochondrial Proton-Translocating ATPasesNeural Stem CellsMitochondrial Proton-Translocating ATPasesArctic ground squirrelcell biologygeneticsgenomicsischemic tolerancemitochondria

Identifiers

PMID33050999
PMCPMC7671683
OpenAlexW3092397595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.