Evidence map›Paper›PMID 33050976›Full record

ArticleJournal of the International Neuropsychological Society : JINS2021

Worth the Wait: Delayed Recall after 1 Week Predicts Cognitive and Medial Temporal Lobe Trajectories in Older Adults.

Cutter A Lindbergh, Nicole Walker, Renaud La Joie, Sophia Weiner-Light, Adam M Staffaroni, Kaitlin B Casaletto, Fanny Elahi, Samantha M Walters, Michelle You, Devyn Cotter and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

Cutter A LindberghMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-9329-4663
Nicole WalkerMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Renaud La JoieMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-2581-8100
Sophia Weiner-LightMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Adam M StaffaroniMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Kaitlin B CasalettoMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Fanny ElahiMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Samantha M WaltersMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Michelle YouMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Devyn CotterMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Breton AskenMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8419-142X
Alexandra C AppleMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Elena TsoyMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
John NeuhausDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Corrina FonsecaMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Amy WolfMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Yann CobigoMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Howie RosenMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Joel H KramerMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Hillblom Aging Network
University of California, San Francisco · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, YADONG · 2004 to 2018
$27.1M
Mechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3M
Biological Predictors Of Brain Aging Trajectories Diversity Supplement: African American Outreach And The Intersection Between Social Determinants Of Health And Biomarkers Of Degenerative DiseaseRF1AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2020 to 2021
$5.3M
Effects of chronic inflammation on brain structure and functionR01AG048234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2015 to 2019
$3.2M
Multimodal Imaging in Frontotemporal DegenerationK24AG045333 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSEN, HOWARD J · 2013 to 2023
$1.9M
Can Behavior Shape Neural Health? Identifying Modifiable Factors to Prevent Cognitive Decline in AgeK23AG058752 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B · 2018 to 2022
$994k
Optimizing Clinical Trial Endpoints in Frontotemporal DementiaK23AG061253 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STAFFARONI, ADAM MARK · 2019 to 2023
$946k
NIA NIH HHS K23 AG058752NIA NIH HHS K23 AG061253NIA NIH HHS K24 AG045333NIA NIH HHS L30 AG057123NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG032289NIA NIH HHS R01 AG048234NIA NIH HHS RF1 AG032289
6 · The paper itself

Abstract

OBJECTIVE WE EVALUATED WHETHER MEMORY RECALL FOLLOWING AN EXTENDED (1 WEEK) DELAY PREDICTS COGNITIVE AND BRAIN STRUCTURAL TRAJECTORIES IN OLDER ADULTS:

methodClinically normal older adults (52-92 years old) were followed longitudinally for up to 8 years after completing a memory paradigm at baseline [Story Recall Test (SRT)] that assessed delayed recall at 30 min and 1 week. Subsets of the cohort underwent neuroimaging (N = 134, mean age = 75) and neuropsychological testing (N = 178-207, mean ages = 74-76) at annual study visits occurring approximately 15-18 months apart. Mixed-effects regression models evaluated if baseline SRT performance predicted longitudinal changes in gray matter volumes and cognitive composite scores, controlling for demographics.

resultsWorse SRT 1-week recall was associated with more precipitous rates of longitudinal decline in medial temporal lobe volumes (p = .037), episodic memory (p = .003), and executive functioning (p = .011), but not occipital lobe or total gray matter volumes (demonstrating neuroanatomical specificity; p > .58). By contrast, SRT 30-min recall was only associated with longitudinal decline in executive functioning (p = .044).

conclusionsMemory paradigms that capture longer-term recall may be particularly sensitive to age-related medial temporal lobe changes and neurodegenerative disease trajectories. (JINS, 2020, xx, xx-xx).

Indexed as

Cognitive DysfunctionMemory, EpisodicNeurodegenerative DiseasesAgedAged, 80 and overCognitionHumansMagnetic Resonance ImagingMiddle AgedNeuropsychological TestsTemporal LobeAlzheimer’s diseaseCognitive agingEarly diagnosisEpisodic memoryLearningTemporal lobe

Identifiers

PMID33050976
PMCPMC8026481
OpenAlexW3091914354

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.