Evidence map›Paper›PMID 33050827›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

A local-neighborhood Lassen plot filter for creating occupancy and non-displaceable binding images.

Bart de Laat, Evan D Morris

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 0 citations in OpenAlex.

  1. Receptor subtype distribution from PET occupancy studies: Novel analysis of maximum occupancy images using a selective drug and a non-selective tracer.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  2. Article
  3. Brain PET imaging usingJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  4. Article
  5. Kinetic models for estimating occupancy from single-scan PET displacement studies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  6. ECEuropean journal of nuclear medicine and molecular imaging · 2022
    Article
  7. NRM 2021 Abstract Booklet.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bart de LaatDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID 0000-0001-8288-8389
Evan D MorrisDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
PET imaging of Naltrexone Occupancy of Kappa Receptors in Heavy DrinkersR01AA021818 · NIAAA · YALE UNIVERSITY · PI KRISHNAN-SARIN, SUCHITRA, MORRIS, EVAN D · 2013 to 2019
$3.4M
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS R01 AA021818
6 · The paper itself

Abstract

For radioligands without a reference region, the Lassen plot can be used to estimate receptor occupancy by an exogenous drug (

Indexed as

AlgorithmsCarbon RadioisotopesFlumazenilGABA ModulatorsHumansImidazolesPositron-Emission TomographyPyridazinesRadiopharmaceuticalsCarbon RadioisotopesFlumazenilGABA ModulatorsImidazolesPF-06372865PyridazinesRadiopharmaceuticalsLassen plotLassen plot filternon-displaceable bindingoccupancypositron emission tomography

Identifiers

PMID33050827
PMCPMC8142134
OpenAlexW3032965493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.