Evidence map›Paper›PMID 33050826›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Impaired capillary-to-arteriolar electrical signaling after traumatic brain injury.

Amreen Mughal, Adrian M Sackheim, Maria Sancho, Thomas A Longden, Sheila Russell, Warren Lockette, Mark T Nelson, Kalev Freeman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Cerebral capillary computation.American journal of physiology. Cell physiology · 2026
    Review
  3. Persistent dysmorphology and dysfunction of the brain microvasculature following repeated trauma.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  4. Review
  5. Article
  6. Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  7. Review
  8. Endothelial KAmerican journal of physiology. Heart and circulatory physiology · 2023
    Article
  9. Review
  10. Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Amreen MughalDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.
Adrian M SackheimDepartment of Surgery, University of Vermont, Burlington, VT, USA.
Maria SanchoDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.
Thomas A LongdenDepartment of Physiology, School of Medicine, University of Maryland, Baltimore, MD, USA.
Sheila RussellDepartment of Surgery, University of Vermont, Burlington, VT, USA.
Warren LocketteDepartment of Internal Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
Mark T NelsonDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.
Kalev FreemanDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.
University of Vermont · USUniversity of Manchester · GBUniversity of Maryland, Baltimore · USWayne State University · US

Funding

Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseR35HL140027 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2025
$6.3M
Ca2+ Sparks and Urinary Bladder Smooth Muscle ExcitabilityR37DK053832 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2008 to 2017
$3.4M
Ion Channel Dysfunction in Small Vessel Disease of the BrainR01NS110656 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2023
$2.6M
Impact of Trauma and its Products on Vascular Endothelial FunctionR01GM123010 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI FREEMAN, KALEV · 2017 to 2021
$1.5M
NHLBI NIH HHS R35 HL140027NIDDK NIH HHS R37 DK053832NIGMS NIH HHS R01 GM123010NINDS NIH HHS R01 NS110656
6 · The paper itself

Abstract

Traumatic brain injury (TBI) acutely impairs dynamic regulation of local cerebral blood flow, but long-term (>72 h) effects on functional hyperemia are unknown. Functional hyperemia depends on capillary endothelial cell inward rectifier potassium channels (Kir2.1) responding to potassium (K

Indexed as

AnimalsArteriolesBrain Injuries, TraumaticCapillariesCerebrovascular CirculationEndothelial CellsHemodynamicsMaleMiceMice, Inbred C57BLPotassium Channels, Inwardly RectifyingSignal TransductionKir2.1 channelPotassium Channels, Inwardly Rectifyingcapillary endothelial cellsCerebral blood flowfunctional hyperemiainward rectifier K+ channels (Kir2.1)traumatic brain injury

Identifiers

PMID33050826
PMCPMC8142130
OpenAlexW3092224859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.