ReviewPharmaceutics2020
Pharmaceutical Hydrates Analysis-Overview of Methods and Recent Advances.
Review in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Hidden Solid-State Transformation of Darunavir in Low-Temperature Hot-Melt-Extruded Granules: Implications for Pharmacy Compounding and Routine Quality Control.Pharmaceutics · 2026Article
- Hydration control in molecular salts through counterion selection.Nature communications · 2026Article
- Multicomponent Salts of the Antidiabetic Agent Saxagliptin: Hydration-Assisted Assembly and Lipophilic Aggregation with Carboxylic Acids.ACS omega · 2026Article
- Granulation Methods and the Mechanisms for Improving Hardness of Loxoprofen Sodium Hydrate-Containing Tablets.Pharmaceutics · 2025Article
- Thermooxidation of Four Sartans: Kinetic Analysis Based on Thermo-Gravimetric Data.Molecules (Basel, Switzerland) · 2024Article
- The Continuous and Reversible Transformation of the Polymorphs of an MGAT2 Inhibitor (S-309309) from the Anhydrate to the Hydrate in Response to Relative Humidity.Pharmaceutics · 2024Article
- Molecular Insights into Water-Chloride and Water-Water Interactions in the Supramolecular Architecture of Aconine Hydrochloride Dihydrate.ACS omega · 2024Article
- Effect of Hydration Forms and Polymer Grades on Theophylline Controlled-Release Tablet: An Assessment and Evaluation.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Multiple Natural Polymers in Drug and Gene Delivery Systems.Current medicinal chemistry · 2024Review
- Density Functional Theory and Density Functional Tight Binding Studies of Thiamine Hydrochloride Hydrates.Molecules (Basel, Switzerland) · 2023Article
- Critical Influence of Water on the Polymorphism of 1,3-Dimethylurea and Other Heterogeneous Equilibria.Molecules (Basel, Switzerland) · 2023Article
- Mechanosynthesis of Stable Salt Hydrates of Allopurinol with Enhanced Dissolution, Diffusion, and Pharmacokinetics.ACS omega · 2023Article
- Rectal Bioavailability of Amoxicillin from Hollow-Type Suppositories: Effect of Chemical Form of Amoxicillin.Pharmaceutics · 2023Article
- Metabolomics in Acute Kidney Injury: The Clinical Perspective.Journal of clinical medicine · 2023Review
- Metabolomics in Acute Kidney Injury: The Experimental Perspective.Journal of clinical medicine research · 2023Review
- New Solid Forms of Nitrofurantoin and 4-Aminopyridine Salt: Influence of Salt Hydration Level on Crystal Packing and Physicochemical Properties.Molecules (Basel, Switzerland) · 2022Article
- Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy.Molecules (Basel, Switzerland) · 2022Article
- Crystalline Hydrate Dehydration Sensing Based on Integrated Terahertz Whispering Gallery Mode Resonators.Sensors (Basel, Switzerland) · 2022Article
- Integral Role of Water in the Solid-State Behavior of the Antileishmanial Drug Miltefosine.Crystal growth & design · 2022Article
- Complexation: An Interesting Pathway for Combining Two APIs at the Solid State.Pharmaceutics · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
This review discusses a set of instrumental and computational methods that are used to characterize hydrated forms of APIs (active pharmaceutical ingredients). The focus has been put on highlighting advantages as well as on presenting some limitations of the selected analytical approaches. This has been performed in order to facilitate the choice of an appropriate method depending on the type of the structural feature that is to be analyzed, that is, degree of hydration, crystal structure and dynamics, and (de)hydration kinetics. The presented techniques include X-ray diffraction (single crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD)), spectroscopic (solid state nuclear magnetic resonance spectroscopy (ssNMR), Fourier-transformed infrared spectroscopy (FT-IR), Raman spectroscopy), thermal (differential scanning calorimetry (DSC), thermogravimetric analysis (TGA)), gravimetric (dynamic vapour sorption (DVS)), and computational (molecular mechanics (MM), Quantum Mechanics (QM), molecular dynamics (MD)) methods. Further, the successful applications of the presented methods in the studies of hydrated APIs as well as studies on the excipients' influence on these processes have been described in many examples.
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