Evidence map›Paper›PMID 33050588›Full record

ArticleNutrients2020

Daily Oral Administration of Protease-Treated Royal Jelly Protects Against Denervation-Induced Skeletal Muscle Atrophy.

Tomohiko Shirakawa, Aki Miyawaki, Takuma Matsubara, Nobuaki Okumura, Hideto Okamoto, Naoya Nakai, Thira Rojasawasthien, Kazumasa Morikawa, Asako Inoue, Akino Goto and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Genome Editing to Abrogate Muscle Atrophy.Advances in experimental medicine and biology · 2023
    Review
  10. Article
  11. Article
  12. Natural Compounds Attenuate Denervation-Induced Skeletal Muscle Atrophy.International journal of molecular sciences · 2021
    Review
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Tomohiko ShirakawaDivision of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Fukuoka 803-8580, Japan.
Aki MiyawakiDivision of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Fukuoka 803-8580, Japan.
Takuma MatsubaraDivision of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Fukuoka 803-8580, Japan.ORCID 0000-0002-8505-0431
Nobuaki OkumuraInstitute for Bee Products and Health Science, Yamada Bee Company, Inc., Tomata, Okayama 708-0393, Japan.
Hideto OkamotoInstitute for Bee Products and Health Science, Yamada Bee Company, Inc., Tomata, Okayama 708-0393, Japan.
Naoya NakaiDivision of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Fukuoka 803-8580, Japan.
Thira RojasawasthienDivision of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Fukuoka 803-8580, Japan.
Kazumasa MorikawaDivision of Pediatric and Special Care Dentistry, Department of Developmental Oral Health Science, School of Dentistry, Iwate Medical University, Shiwa, Iwate 028-3694, Japan.
Asako InoueDivision of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Fukuoka 803-8580, Japan.
Akino GotoDivision of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Fukuoka 803-8580, Japan.
Ayako WashioDivision of Endodontics and Restorative Dentistry, Department of Oral Functions, Kyushu Dental University, Kitakyushu, Fukuoka 803-8580, Japan.
Toshiyuki TsujisawaSchool of Oral Health Sciences, Kyushu Dental University, Kitakyushu, Fukuoka 803-8580, Japan.
Tatsuo KawamotoDivision of Orofacial Functions and Orthodontics, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Fukuoka 803-8580, Japan.
Shoichiro KokabuDivision of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Fukuoka 803-8580, Japan.
Kyushu Dental University · JPIwate Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Honeybees produce royal jelly (RJ) from their cephalic glands. Royal jelly is a source of nutrition for the queen honey bee throughout its lifespan and is also involved in fertility and longevity. Royal jelly has long been considered beneficial to human health. We recently observed that RJ delayed impairment of motor function during aging, affecting muscle fiber size. However, how RJ affects skeletal muscle metabolism and the functional component of RJ is as of yet unidentified. We demonstrate that feeding mice with RJ daily prevents a decrease in myofiber size following denervation without affecting total muscle weight. RJ did not affect atrophy-related genes but stimulated the expression of myogenesis-related genes, including

Indexed as

Administration, OralAnimalsCells, CulturedDecanoic AcidsDenervationFatty AcidsFatty Acids, MonounsaturatedInsulin-Like Growth Factor IMice, Inbred C57BLMuscle DevelopmentMuscle, SkeletalMuscular AtrophyMyoblastsPeptide HydrolasesReceptor, IGF Type 1Royal Jelly10-hydroxy-2-decenoic acid10-hydroxydecanoic acidDecanoic AcidsFatty AcidsFatty Acids, MonounsaturatedInsulin-Like Growth Factor IPeptide HydrolasesReceptor, IGF Type 1Royal Jellyatrophydenervationmyoblastsroyal jellyskeletal muscle

Identifiers

PMID33050588
PMCPMC7600733
OpenAlexW3092520978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.