ReviewCancers2020
Tumor Microenvironment as a Regulator of Radiation Therapy: New Insights into Stromal-Mediated Radioresistance.
Open access · goldAbstract readReview
In one paragraph
Review in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
4.9field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 108 citations in OpenAlex.
- VMAT-based lattice radiotherapy for advanced bulky hepatocellular carcinoma within multimodality treatment: a consecutive feasibility series.Clinical and translational radiation oncology · 2026Article
- Understanding and targeting the tumour matrisome.Nature reviews. Clinical oncology · 2026Review
- Evolutionary Double-Bind Treatment Using Radiation Therapy and Natural Killer Cell-Based Immunotherapy in Prostate Cancer.International journal of radiation oncology, biology, physics · 2026Article
- Reprogramming the tumor immune microenvironment in cervical cancer: synergy between radiotherapy and immunotherapy.Molecular cancer · 2026Review
- Organ-on-a-chip systems for modeling tumor and normal tissue microenvironments in radiotherapy research.Trends in biotechnology · 2026Review
- Optimized patient-derived lung cancer organoids recapitulating the immune landscape for precision therapy evaluation.Cellular oncology (Dordrecht, Netherlands) · 2026Article
- The radioresistance of clinically relevant radioresistant cell-derived tumors is determined by the cancer cells themselves, rather than by the surrounding stromal cells.Journal of dental sciences · 2026Article
- Key Tumor Responsive ZIF-8 Nanocarriers for Effective Anti-Cancer Therapeutics.International journal of nanomedicine · 2026Review
- From immune exclusion to exhaustion: tumor microenvironment drives therapy response.Frontiers in immunology · 2026Review
- Risk stratification and multi-omics reveal RAD51 inhibition as a radiosensitizing strategy in triple-negative breast cancer.Frontiers in immunology · 2026Article
- Biologically effective doses for α/β = 10 (BEDFrontiers in oncology · 2026Article
- Relationship between fibrosis induced by preoperative chemoradiotherapy and real-time tissue elastography of internal anal sphincter.International journal of colorectal disease · 2025Article
- [Mechanistic research progress on radiotherapy resistance of cancer stem cells].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- A lung tumor-on-a-chip model recapitulates the effect of hypoxia on radiotherapy response and FDG-PET imaging.Lab on a chip · 2025Article
- Redefining Chemoresistance: Natural Bioactives as Molecular Modulators at the Cancer-Tumor Microenvironment Interface.International journal of molecular sciences · 2025Review
- DDX42 Enhances Hepatocellular Carcinoma Cell Proliferation, Radiation and Sorafenib Resistance via Regulating GRB2 RNA Maturation and Activating PI3K/AKT Pathway.Journal of cellular and molecular medicine · 2025Article
- A Lung Tumor-on-a-Chip Model Recapitulates the Effect of Hypoxia on Radiotherapy Response and FDG-PET Imaging.bioRxiv : the preprint server for biology · 2025Article
- Role ofJournal of thoracic disease · 2025Article
- Targeting the Enhanced Sensitivity of Radiotherapy in Cancer: Mechanisms, Applications, and Challenges.MedComm · 2025Review
- Radiation Damage to a Three-Dimensional Hydrogel Model of the Brain Perivascular Niche.Tissue engineering. Part C, Methods · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Varintra E KrisnawanDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jennifer A StanleyDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Julie K SchwarzDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-2407-7531
David G DeNardoDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Washington University in St. Louis · US
Funding
Washington University SPORE in Pancreatic CancerP50CA196510 · NCI · WASHINGTON UNIVERSITY · PI HAWKINS, WILLIAM G · 2016 to 2020
$10.9MThe Impact of Macrophage Origin on the Pathogenesis and Treatment Resistance of Pancreatic CancerR01CA177670 · NCI · WASHINGTON UNIVERSITY · PI DENARDO, DAVID G · 2014 to 2023
$3.3MTargeting Focal Adhesion Kinase to Improve RT-inducted Tumor ImmunityR01CA248917 · NCI · WASHINGTON UNIVERSITY · PI DENARDO, DAVID G, KIM, HYUN · 2020 to 2024
$2.5MExploiting Integrin Signaling to Overcome Resistance to ImmunotherapyR01CA244938 · NCI · WASHINGTON UNIVERSITY · PI DENARDO, DAVID G, GUPTA, VINEET · 2020 to 2024
$2.2MCOMBINED TUMOR AND STROMAL TARGETING TO IMPROVE PANCREATIC CANCER RESPONSE TO IMMUNOTHERAPYR01CA203890 · NCI · WASHINGTON UNIVERSITY · PI DENARDO, DAVID G · 2016 to 2020
$1.7MElucidating the protective role of stromal fibrosis to radiation-induced tumor immunityF30CA243233 · NCI · WASHINGTON UNIVERSITY · PI LANDER, VARINTRA EDLYN · 2019 to 2022
$165kAmerican Association for Cancer Research AACR/Bristol Meyers Squibb Female Investigator AwardNCI NIH HHS F30 CA243233NCI NIH HHS F30CA243233NCI NIH HHS P50 CA196510NCI NIH HHS P50CA196510NCI NIH HHS R01 CA177670NCI NIH HHS R01CA177670NCI NIH HHS R01 CA203890NCI NIH HHS R01CA203890NCI NIH HHS R01 CA244938NCI NIH HHS R01CA244938NCI NIH HHS R01 CA248917NCI NIH HHS R01CA248917NCI NIH HHS U2CCA223303RNSA Research Resident/Fellow Grant RR2062Siteman Investment Program N/A
Abstract
PubMed holds no abstract for this paper.
Indexed as
cancer-associated fibroblast (CAF)cytokine/chemokineextracellular matrix (ECM)growth factorsimmunomodulatory rolespro- and anti-tumor immune cellsradioresistanceradiosensitivityradiotherapy dose fractionationstroma
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.