Evidence map›Paper›PMID 33050524›Full record

ArticleMolecules (Basel, Switzerland)2020

Synthesis, Docking, 3-D-Qsar, and Biological Assays of Novel Indole Derivatives Targeting Serotonin Transporter, Dopamine D2 Receptor, and Mao-A Enzyme: In the Pursuit for Potential Multitarget Directed Ligands.

Christopher Cerda-Cavieres, Gabriel Quiroz, Patricio Iturriaga-Vásquez, Julio Rodríguez-Lavado, Jazmín Alarcón-Espósito, Claudio Saitz, Carlos D Pessoa-Mahana, Hery Chung, Ramiro Araya-Maturana, Jaime Mella-Raipán and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Christopher Cerda-CavieresDepartamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Casilla 233, Santiago 8380494, Chile.
Gabriel QuirozPrograma de Doctorado en Farmacología, Universidad de Chile, Santiago 8380453, Chile.
Patricio Iturriaga-VásquezDepartamento de Ciencias Químicas y Recursos Naturales, Facultad de Ingeniería y Ciencias, Universidad de la Frontera, Temuco 4811230, Chile.ORCID 0000-0003-0553-1014
Julio Rodríguez-LavadoDepartamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Casilla 233, Santiago 8380494, Chile.
Jazmín Alarcón-EspósitoDepartamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Casilla 233, Santiago 8380494, Chile.
Claudio SaitzDepartamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Casilla 233, Santiago 8380494, Chile.
Carlos D Pessoa-MahanaDepartamento de Farmacia, Facultad de Química, Pontificia Universidad Católica de Chile, Santiago 7820244, Chile.
Hery ChungDepartamento de Farmacia, Facultad de Química, Pontificia Universidad Católica de Chile, Santiago 7820244, Chile.ORCID 0000-0001-8992-0337
Ramiro Araya-MaturanaInstituto de Química y Recursos Naturales, Universidad de Talca, Talca 3460000, Chile.ORCID 0000-0002-5082-9146
Jaime Mella-RaipánInstituto de Química y Bioquímica, Facultad de Ciencias, Universidad de Valparaíso, Av. Gran Bretaña 1111, Valparaíso 2360102, Chile.ORCID 0000-0002-2434-8461
David CabezasInstituto de Química y Bioquímica, Facultad de Ciencias, Universidad de Valparaíso, Av. Gran Bretaña 1111, Valparaíso 2360102, Chile.
Claudia Ojeda-GómezColegio Instituto San Martín, Hermanos Maristas, Curicó 3341965, Chile.
Miguel Reyes-ParadaCentro de Investigación Biomédica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago 9170002, Chile.ORCID 0000-0002-2376-990X
Hernán Pessoa-MahanaDepartamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Casilla 233, Santiago 8380494, Chile.
University of Chile · CLPontificia Universidad Católica de Chile · CLUniversity of Valparaíso · CLUniversidad de La Frontera · CLUniversidad de Santiago de Chile · CLUniversity of Talca · CL

Funding

Cardiometabolic Outcomes, Mechanisms and approach to prevention of Dolutegravir Associated Weight Gain In South AfricaR21TW011706 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KENGNE, ANDRE PASCAL, NACHEGA, JEAN BISIMWA · 2020 to 2021
$345k
Fondo Nacional de Desarrollo Científico y Tecnológico 1170269Fondo Nacional de Desarrollo Científico y Tecnológico 1170662Fondo Nacional de Desarrollo Científico y Tecnológico 3180602
6 · The paper itself

Abstract

A series of 27 compounds of general structure 2,3-dihydro-benzo[1,4]oxazin-4-yl)-2-{4-[3-(1

Indexed as

Biological AssayMolecular Docking SimulationQuantitative Structure-Activity RelationshipReceptors, Dopamine D2Serotonin Plasma Membrane Transport ProteinsStructure-Activity RelationshipReceptors, Dopamine D2Serotonin Plasma Membrane Transport Proteins3-indolylpropylpiperazinesdockingdopamine D2 receptormultitargetpolypharmacologyQSARSERT

Identifiers

PMID33050524
PMCPMC7594025
OpenAlexW3091956121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.