Evidence map›Paper›PMID 33050335›Full record

ArticleInternational journal of molecular sciences2020

Eicosanoid Profiles in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy.

Albert L Lin, Richard J Roman, Kathleen A Regan, Charlotte A Bolch, Ching-Jygh Chen, Siva S R Iyer

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Albert L LinDepartment of Ophthalmology, University of Mississippi School of Medicine, Jackson, MS 39216, USA.
Richard J RomanDepartment of Pharmacology and Toxicology, University of Mississippi School of Medicine, Jackson, MS 39216, USA.ORCID 0000-0002-5581-0217
Kathleen A ReganDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA.ORCID 0000-0003-0504-3053
Charlotte A BolchDepartment of Ophthalmology, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0002-9797-6557
Ching-Jygh ChenDepartment of Ophthalmology, University of Mississippi School of Medicine, Jackson, MS 39216, USA.
Siva S R IyerDepartment of Ophthalmology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
University of Mississippi · USUniversity of Florida · US

Funding

The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Genetic determinants of hypertension-induced cerebral vascular dysfunctionR01HL138685 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROMAN, RICHARD J. · 2018 to 2021
$1.9M
Renal microcirculation and hypertension induced renal injuryR01DK104184 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROMAN, RICHARD J. · 2014 to 2017
$1.8M
NHLBI NIH HHS R01 HL138685NIDDK NIH HHS R01 DK104184NIGMS NIH HHS P20 GM104357NIH HHS DK104184NIH HHS HL138685NIH HHS P20GM104357Research to Prevent Blindness Departmental GrantUniversity of Mississippi Intramural Research Program Grant
6 · The paper itself

Abstract

Proliferative diabetic retinopathy is a potentially blinding sequela of uncontrolled diabetes that involves a complex interaction of pro-angiogenic and inflammatory pathways. In this study, we compared the levels of pro-angiogenic arachidonic acid-derived mediators in human vitreous humor obtained from eyes with high-risk proliferative diabetic retinopathy versus controls. The results indicated that lipoxygenase and cytochrome P450-derived eicosanoids were elevated (5-HETE, 12-HETE, 20-HETE, and 20-COOH-AA)

Indexed as

BiomarkersChromatography, LiquidDiabetic RetinopathyDisease SusceptibilityEicosanoidsFemaleHumansMaleRetinal DetachmentTandem Mass SpectrometryVitreous BodyBiomarkersEicosanoidseicosanoidsproliferative diabetic retinopathytractional retinal detachmentvitreous

Identifiers

PMID33050335
PMCPMC7589012
OpenAlexW3092281897

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.