Evidence map›Paper›PMID 33050281›Full record

ArticleMaterials (Basel, Switzerland)2020

Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes.

Francesca Posa, Adriana Di Benedetto, Giampietro Ravagnan, Elisabetta Ada Cavalcanti-Adam, Lorenzo Lo Muzio, Gianluca Percoco, Giorgio Mori

Open access · goldAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Surgery Training System Supported by Organic Materials.Materials (Basel, Switzerland) · 2022
    Article
  5. Article
  6. Design of Materials for Bone Tissue Scaffolds.Materials (Basel, Switzerland) · 2021
    Article
  7. Advances in 3D Printing for Tissue Engineering.Materials (Basel, Switzerland) · 2021
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Francesca PosaDepartment of Clinical and Experimental Medicine, University of Foggia, viale Pinto 1, 71122 Foggia, Italy.ORCID 0000-0001-8099-3505
Adriana Di BenedettoDepartment of Clinical and Experimental Medicine, University of Foggia, viale Pinto 1, 71122 Foggia, Italy.
Giampietro RavagnanGlures srl. Unità Operativa di Napoli, Spin off Accademico dell'Università di Venezia Cà Foscari, Via delle Industrie 19b-30175 Venezia, Italy.
Elisabetta Ada Cavalcanti-AdamDepartment of Biophysical Chemistry, Heidelberg University and Max Planck Institute for Medical Research, Jahnstraße 29, 69120 Heidelberg, Germany.ORCID 0000-0003-0243-1552
Lorenzo Lo MuzioDepartment of Clinical and Experimental Medicine, University of Foggia, viale Pinto 1, 71122 Foggia, Italy.ORCID 0000-0003-4633-4893
Gianluca PercocoDepartment of Mechanics, Mathematics and Management, Polytechnic University of Bari, Via E. Orabona 4, 70125 Bari, Italy.
Giorgio MoriDepartment of Clinical and Experimental Medicine, University of Foggia, viale Pinto 1, 71122 Foggia, Italy.ORCID 0000-0001-6731-0247
University of Foggia · ITCa' Foscari University of Venice · ITHeidelberg University · DEPolytechnic University of Bari · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca PRIN 20098KM9RN, PI G.M. (Progetto di Ricerca d'Interesse Nazionale-Grant 2009)
6 · The paper itself

Abstract

Diseases determining bone tissue loss have a high impact on people of any age. Bone healing can be improved using a therapeutic approach based on tissue engineering. Scientific research is demonstrating that among bone regeneration techniques, interesting results, in filling of bone lesions and dehiscence have been obtained using adult mesenchymal stem cells (MSCs) integrated with biocompatible scaffolds. The geometry of the scaffold has critical effects on cell adhesion, proliferation and differentiation. Many cytokines and compounds have been demonstrated to be effective in promoting MSCs osteogenic differentiation. Oligostilbenes, such as Resveratrol (Res) and Polydatin (Pol), can increase MSCs osteoblastic features. 3D printing is an excellent technique to create scaffolds customized for the lesion and thus optimized for the patient. In this work we analyze osteoblastic features of adult MSCs integrated with 3D-printed polycarbonate scaffolds differentiated in the presence of oligostilbenes.

Indexed as

biomaterialbonebone healthfocal adhesionsmesenchymal stem cellsosteogenic differentiationpolycarbonatepolydatinresveratrol

Identifiers

PMID33050281
PMCPMC7601568
OpenAlexW3092602181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.