Evidence map›Paper›PMID 33050177›Full record

ArticleCancers2020

Direct Transfer of Mesoporous Silica Nanoparticles between Macrophages and Cancer Cells.

Stefan Franco, Achraf Noureddine, Jimin Guo, Jane Keth, Michael L Paffett, C Jeffrey Brinker, Rita E Serda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Tunneling Nanotubes: A New Target for Nanomedicine?International journal of molecular sciences · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stefan FrancoInternal Medicine, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.ORCID 0000-0002-2470-8199
Achraf NoureddineDepartment of Chemical and Biological Engineering, University of New Mexico, Albuquerque, NM 87131, USA.ORCID 0000-0001-9530-5963
Jimin GuoInternal Medicine, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
Jane KethInternal Medicine, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
Michael L PaffettFluorescence Microscopy Shared Resource, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87131, USA.
C Jeffrey BrinkerDepartment of Chemical and Biological Engineering, University of New Mexico, Albuquerque, NM 87131, USA.
Rita E SerdaInternal Medicine, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.

Funding

NIH HHS NCI 2P30 CA118100
6 · The paper itself

Abstract

Macrophages line the walls of microvasculature, extending processes into the blood flow to capture foreign invaders, including nano-scale materials. Using mesoporous silica nanoparticles (MSNs) as a model nano-scale system, we show the interplay between macrophages and MSNs from initial uptake to intercellular trafficking to neighboring cells along microtubules. The nature of cytoplasmic bridges between cells and their role in the cell-to-cell transfer of nano-scale materials is examined, as is the ability of macrophages to function as carriers of nanomaterials to cancer cells. Both direct administration of nanoparticles and adoptive transfer of nanoparticle-loaded splenocytes in mice resulted in abundant localization of nanomaterials within macrophages 24 h post-injection, predominately in the liver. While heterotypic, trans-species nanomaterial transfer from murine macrophages to human HeLa cervical cancer cells or A549 lung cancer cells was robust, transfer to syngeneic 4T1 breast cancer cells was not detected in vitro or in vivo. Cellular connections and nanomaterial transfer in vivo were rich among immune cells, facilitating coordinated immune responses.

Indexed as

cancerdoxorubicinintercellular transportmacrophagemesoporous silica nanoparticletunneling nanotubes

Identifiers

PMID33050177
PMCPMC7600949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.