ReviewBiomolecules2020
Composition and Function of Telomerase-A Polymerase Associated with the Origin of Eukaryotes.
Review in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Genetic Determinants of Telomere Length and Their Role in Human Disease: Molecular Mechanisms and Underrepresented Populations' Perspectives.Biomedicines · 2026Review
- La protein binding to telomerase RNA supports an evolutionary relationship between plant and ciliate telomerase pathways.Nucleic acids research · 2026Article
- Association Between Metabolic Syndrome Components, Clinical Characteristics, and Telomere Length: Factor Analysis of Mixed Data Based Cluster Analysis of LIPIDOGEN2015 Cross-Sectional Study.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Beyond the ends: potential implications of telomeric repeat-containing RNA (TERRA) for CNS diseases.Journal of molecular cell biology · 2025Review
- Parental clinical manifestation association with newborn immune senescence and telomere biology in Pakistan.BMC research notes · 2025Article
- Potential Active Compounds ofFood science & nutrition · 2025Review
- The role of telomere and telomerase in cancer and novel therapeutic target: narrative review.Frontiers in oncology · 2025Review
- Telomeres: an organized string linking plants and mammals.Biology direct · 2024Review
- Reconstructing the last common ancestor of all eukaryotes.PLoS biology · 2024Review
- Atlas of telomeric repeat diversity in Arabidopsis thaliana.Genome biology · 2024Article
- Renal tubular epithelial cell quality control mechanisms as therapeutic targets in renal fibrosis.Journal of pharmaceutical analysis · 2024Review
- Characterisation of the Arabidopsis thaliana telomerase TERT-TR complex.Plant molecular biology · 2024Article
- Article
- Telomeres and Their Neighbors.Genes · 2022Review
- Artificial chromosome technology and its potential application in plants.Frontiers in plant science · 2022Review
- Telomerase Interaction Partners-Insight from Plants.International journal of molecular sciences · 2021Article
- Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer.Biochemistry and biophysics reports · 2021Review
- Extraordinary diversity of telomeres, telomerase RNAs and their template regions in Saccharomycetaceae.Scientific reports · 2021Article
- Telomerase in Brain: The New Kid on the Block and Its Role in Neurodegenerative Diseases.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The canonical DNA polymerases involved in the replication of the genome are unable to fully replicate the physical ends of linear chromosomes, called telomeres. Chromosomal termini thus become shortened in each cell cycle. The maintenance of telomeres requires telomerase-a specific RNA-dependent DNA polymerase enzyme complex that carries its own RNA template and adds telomeric repeats to the ends of chromosomes using a reverse transcription mechanism. Both core subunits of telomerase-its catalytic telomerase reverse transcriptase (TERT) subunit and telomerase RNA (TR) component-were identified in quick succession in Tetrahymena more than 30 years ago. Since then, both telomerase subunits have been described in various organisms including yeasts, mammals, birds, reptiles and fish. Despite the fact that telomerase activity in plants was described 25 years ago and the TERT subunit four years later, a genuine plant TR has only recently been identified by our group. In this review, we focus on the structure, composition and function of telomerases. In addition, we discuss the origin and phylogenetic divergence of this unique RNA-dependent DNA polymerase as a witness of early eukaryotic evolution. Specifically, we discuss the latest information regarding the recently discovered TR component in plants, its conservation and its structural features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.