Evidence map›Paper›PMID 33050052›Full record

ArticleInternational journal of molecular sciences2020

Discovery of Novel Fetal Hemoglobin Inducers through Small Chemical Library Screening.

Giulia Breveglieri, Salvatore Pacifico, Cristina Zuccato, Lucia Carmela Cosenza, Shaiq Sultan, Elisabetta D'Aversa, Roberto Gambari, Delia Preti, Claudio Trapella, Remo Guerrini and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Giulia BreveglieriDepartment of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy.
Salvatore PacificoDepartment of Chemical and Pharmaceutical Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.ORCID 0000-0002-3377-5107
Cristina ZuccatoDepartment of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy.
Lucia Carmela CosenzaDepartment of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy.
Shaiq SultanDepartment of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy.
Elisabetta D'AversaDepartment of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy.
Roberto GambariDepartment of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy.
Delia PretiDepartment of Chemical and Pharmaceutical Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
Claudio TrapellaDepartment of Chemical and Pharmaceutical Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
Remo GuerriniDepartment of Chemical and Pharmaceutical Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
Monica BorgattiDepartment of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy.ORCID 0000-0001-8470-2496
University of Ferrara · IT

Funding

AIFA, ITALY AIFA-2016-02364887FP7 Health 306201-FP7-HEALTH-2012-INNOVATION-1Università degli Studi di Ferrara Bando per il finanziamento di Progetti di Ricerca Interdisciplinari di Ateneo (PRIA)-2014Wellcome Trust Innovator Award 208872/Z/17/Z
6 · The paper itself

Abstract

The screening of chemical libraries based on cellular biosensors is a useful approach to identify new hits for novel therapeutic targets involved in rare genetic pathologies, such as

Indexed as

Anemia, Sickle Cellbeta-Globinsbeta-ThalassemiaBiosensing TechniquesCell DifferentiationCell ProliferationDrug DiscoveryDrug Evaluation, PreclinicalFetal HemoglobinFlow Cytometrygamma-GlobinsGene ExpressionGene Expression RegulationGreen Fluorescent ProteinsHumansK562 Cellsbeta-Globinsenhanced green fluorescent proteinFetal Hemoglobingamma-GlobinsGreen Fluorescent ProteinsLuminescent ProteinsRed Fluorescent ProteinSmall Molecule Librariescellular biosensorschemical screeningcompound libraryfetal hemoglobinhemoglobinopathiessickle cell diseaseβ-thalassemia

Identifiers

PMID33050052
PMCPMC7582302
OpenAlexW3091936764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.