Evidence map›Paper›PMID 33050014›Full record

ArticleInternational journal of molecular sciences2020

Comprehensive Analysis of Antibodies Induced by Vaccination with 4 Kinds of Avian Influenza H5N1 Pre-Pandemic Vaccines.

Nobuko Ohshima, Yoshitaka Iba, Ritsuko Kubota-Koketsu, Ayami Yamasaki, Keiko Majima, Gene Kurosawa, Daisuke Hirano, Shunji Yoshida, Mototaka Sugiura, Yoshizo Asano and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nobuko OhshimaInternational Center for Cell and Gene Therapy, Research Promotion and Support Headquarters, Fujita Health University, Toyoake, Aichi 470-1192, Japan.ORCID 0000-0002-9076-1879
Yoshitaka IbaInternational Center for Cell and Gene Therapy, Research Promotion and Support Headquarters, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
Ritsuko Kubota-KoketsuClinical Research Section, Research Department, The Research Foundation for Microbial Disease of Osaka University, Suita, Osaka 565-0871, Japan.
Ayami YamasakiDepartment of Innovation for Advanced Medicine, Center for Research Promotion and Support, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
Keiko MajimaDepartment of Innovation for Advanced Medicine, Center for Research Promotion and Support, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
Gene KurosawaInternational Center for Cell and Gene Therapy, Research Promotion and Support Headquarters, Fujita Health University, Toyoake, Aichi 470-1192, Japan.ORCID 0000-0001-9477-7467
Daisuke HiranoDivision of Rheumatology, Department of Internal Medicine, School of Medicine, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
Shunji YoshidaDivision of Rheumatology, Department of Internal Medicine, School of Medicine, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
Mototaka SugiuraDepartment of Internal Medicine, School of Medicine, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
Yoshizo AsanoDepartment of Pediatrics, School of Medicine, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
Yoshinobu OkunoOsaka Institute of Public Health, Osaka 537-0025, Japan.
Yoshikazu KurosawaDepartment of Innovation for Advanced Medicine, Center for Research Promotion and Support, Fujita Health University, Toyoake, Aichi 470-1192, Japan.

Funding

Japan Agency for Medical Research and Development JP17fk0108306h0003Ministry of Education, Culture, Sports, Science and Technology 17K10037
6 · The paper itself

Abstract

Four kinds of avian-derived H5N1 influenza virus, A/Vietnam/1194/2004 (Clade 1), A/Indonesia/5/2005 (Clade 2.1), A/Qinghai/1A/2005 (Clade 2.2), and A/Anhui/1/2005 (Clade 2.3), have been stocked in Japan for use as pre-pandemic vaccines. When a pandemic occurs, these viruses would be used as vaccines in the hope of inducing immunity against the pandemic virus. We analyzed the specificity of antibodies (Abs) produced by B lymphocytes present in the blood after immunization with these vaccines. Eighteen volunteers took part in this project. After libraries of Ab-encoding sequences were constructed using blood from subjects vaccinated with these viruses, a large number of clones that encoded Abs that bound to the virus particles used as vaccines were isolated. These clones were classified into two groups according to the hemagglutination inhibition (HI) activity of the encoded Abs. While two-thirds of the clones were HI positive, the encoded Abs exhibited only restricted strain specificity. On the other hand, half of the HI-negative clones encoded Abs that bound not only to the H5N1 virus but also to the H1N1 virus; with a few exceptions, these Abs appeared to be encoded by memory B cells present before vaccination. The HI-negative clones included those encoding broadly cross-reactive Abs, some of which were encoded by non-V

Indexed as

AdultAgedAntibodies, ViralB-LymphocytesBroadly Neutralizing AntibodiesCross ReactionsFemaleHealthy VolunteersHemagglutination Inhibition TestsHumansImmunologic MemoryInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H5N1 SubtypeInfluenza, HumanInfluenza VaccinesJapanAntibodies, ViralBroadly Neutralizing AntibodiesInfluenza VaccinesVaccines, InactivatedantibodiesH5N1pre-pandemic vaccines

Identifiers

PMID33050014
PMCPMC7582428

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.