Evidence map›Paper›PMID 33049999›Full record

ArticleMolecules (Basel, Switzerland)2020

Initial In Vitro and In Vivo Evaluation of a Novel CCK2R Targeting Peptide Analog Labeled with Lutetium-177.

Anton Amadeus Hörmann, Maximilian Klingler, Maliheh Rezaeianpour, Nikolas Hörmann, Ronald Gust, Soraya Shahhosseini, Elisabeth von Guggenberg

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Comparison of twoEJNMMI radiopharmacy and chemistry · 2026
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  2. Review
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  4. Molecular pharmaceutics · 2025
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  5. Journal of medicinal chemistry · 2024
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  6. [EJNMMI radiopharmacy and chemistry · 2024
    Article
  7. Article
  8. Effect ofPharmaceutics · 2023
    Article
  9. Article
  10. Automated Synthesis ofMolecules (Basel, Switzerland) · 2022
    Article
  11. Review
  12. Radiopharmaceutical Formulation and Preclinical Testing ofPharmaceuticals (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Anton Amadeus HörmannDepartment of Nuclear Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-0119-3102
Maximilian KlinglerDepartment of Nuclear Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-8499-9434
Maliheh RezaeianpourDepartment of Nuclear Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-0451-6202
Nikolas HörmannDepartment of Pharmaceutical Chemistry, University of Innsbruck, 6020 Innsbruck, Austria.
Ronald GustDepartment of Pharmaceutical Chemistry, University of Innsbruck, 6020 Innsbruck, Austria.
Soraya ShahhosseiniPharmaceutical Chemistry and Radiopharmacy Department, School of Pharmacy, Shahid Beheshti University of Medical Sciences, 1991953381 Tehran, Iran.ORCID 0000-0001-5681-073X
Elisabeth von GuggenbergDepartment of Nuclear Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-4944-4705
Innsbruck Medical University · ATUniversität Innsbruck · ATShahid Beheshti University of Medical Sciences · IR

Funding

Austrian Science Fund P 27844Austrian Science Fund FWF P 27844
6 · The paper itself

Abstract

Targeting of cholecystokinin-2 receptor (CCK2R) expressing tumors using radiolabeled minigastrin (MG) analogs is hampered by rapid digestion of the linear peptide in vivo. In this study, a new MG analog stabilized against enzymatic degradation was investigated in preclinical studies to characterize the metabolites formed in vivo. The new MG analog DOTA-DGlu-Pro-Tyr-Gly-Trp-(

Indexed as

Amino Acid SequenceAmino Acid SubstitutionAnimalsCell Line, TumorFemaleGastrinsHumansLutetiumMiceMice, Inbred BALB CPeptidesRadioisotopesReceptor, Cholecystokinin BTissue DistributionGastrinsLutetiumLutetium-177minigastrinPeptidesRadioisotopesReceptor, Cholecystokinin Bcholecystokinin-2 receptorlutetium-177minigastrinmolecular imagingtargeted radiotherapy

Identifiers

PMID33049999
PMCPMC7583830
OpenAlexW3092293617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.