Evidence map›Paper›PMID 33049994›Full record

ArticleViruses2020

Autoreactivity of Broadly Neutralizing Influenza Human Antibodies to Human Tissues and Human Proteins.

Surender Khurana, Megan Hahn, Laura Klenow, Hana Golding

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Surender KhuranaDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD 20993, USA.
Megan HahnDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD 20993, USA.
Laura KlenowDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD 20993, USA.
Hana GoldingDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD 20993, USA.
Center for Biologics Evaluation and Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Broadly neutralizing monoclonal antibodies (bNAbs) against conserved domains in the influenza hemagglutinin are in clinical trials. Several next generation influenza vaccines designed to elicit such bNAbs are also in clinical development. One of the common features of the isolated bNAbs is the use of restricted IgV

Indexed as

Antibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralAutoantibodiesBroadly Neutralizing AntibodiesHemagglutinin Glycoproteins, Influenza VirusHIV-1HIV AntibodiesHumansImmunoglobulin Heavy ChainsInfluenza, HumanInfluenza VaccinesRibonucleoproteins, Small NuclearSingle-Chain Antibodies4E10 monoclonal antibodyAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralAutoantibodiesBroadly Neutralizing AntibodiesEDC3 protein, humanHemagglutinin Glycoproteins, Influenza VirusHIV AntibodiesImmunoglobulin Heavy ChainsInfluenza VaccinesRibonucleoproteins, Small NuclearSingle-Chain Antibodiesantibody affinityautoreactivitybNAbsheadhemagglutinininfluenzapolyreactivitystemuniversal influenzavaccine

Identifiers

PMID33049994
PMCPMC7600923
OpenAlexW3092251831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.