Evidence map›Paper›PMID 33049918›Full record

ArticleCells2020

Safety and Tolerability of Stromal Vascular Fraction Combined with β-Tricalcium Phosphate in Posterior Lumbar Interbody Fusion: Phase I Clinical Trial.

Un Yong Choi, Kyoung-Tae Kim, Kwang Gi Kim, Sang Heon Lim, Young Jae Kim, Seil Sohn, Seung Hun Sheen, Chan Yeong Heo, Inbo Han

Open access · goldAbstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Emerging Technologies within Spine Surgery.Life (Basel, Switzerland) · 2023
    Review
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Un Yong ChoiDepartment of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Korea.ORCID 0000-0001-9331-1112
Kyoung-Tae KimDepartment of Neurosurgery, School of Medicine, Kyungpook National University, Daegu 41944, Korea.ORCID 0000-0003-4867-6854
Kwang Gi KimDepartment of Biomedical Engineering, College of Medicine, Gachon University, Seongnam-si 13120, Korea.ORCID 0000-0001-9714-6038
Sang Heon LimDepartment of Biomedical Engineering, College of Medicine, Gachon University, Seongnam-si 13120, Korea.ORCID 0000-0002-1298-5180
Young Jae KimDepartment of Biomedical Engineering, College of Medicine, Gachon University, Seongnam-si 13120, Korea.ORCID 0000-0003-0443-0051
Seil SohnDepartment of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Korea.
Seung Hun SheenDepartment of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Korea.ORCID 0000-0002-0454-8810
Chan Yeong HeoDepartment of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam-si 13620, Korea.ORCID 0000-0001-9003-7365
Inbo HanDepartment of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Korea.ORCID 0000-0002-0834-9325
CHA University Bundang Medical Center · KRGachon University · KRSeoul National University Bundang Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rates of pseudarthrosis remain high despite recent advances in bone graft substitutes for spinal fusion surgery. The aim of this single center, non-randomized, open-label clinical trial was to determine the feasibility of combined use of stromal vascular fraction (SVF) and β-tricalcium phosphate (β-TCP) for patients who require posterior lumbar interbody fusion (PLIF) and pedicle screw fixation. Two polyetheretherketone (PEEK) cages were inserted into the intervertebral space following complete removal of the intervertebral disc. The PEEK cage (SVF group) on the right side of the patient was filled with β-TCP in combination with SVF, and the cage on the left side (control group) was filled with β-TCP alone. Fusion rate and cage subsidence were assessed by lumbar spine X-ray and CT at 6 and 12 months postoperatively. At the 6-month follow-up, 54.5% of the SVF group (right-sided cages) and 18.2% of the control group (left-sided cages) had radiologic evidence of bone fusion (

Indexed as

Adipose TissueAgedBenzophenonesCalcium PhosphatesFemaleHumansKetonesMaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMiddle AgedPolyethylene GlycolsPolymersPseudarthrosisSpinal FusionTreatment OutcomeBenzophenonesbeta-tricalcium phosphateCalcium PhosphatesKetonespolyetheretherketonePolyethylene GlycolsPolymersbone graft substituteposterior lumbar interbody fusionspinal stenosisstromal vascular fraction

Identifiers

PMID33049918
PMCPMC7600447
OpenAlexW3092157409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.