ArticleNature2020
Computational planning of the synthesis of complex natural products.
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed.
- Robots and Minimal, Physics-Informed Features: A Hybrid Framework for Enzyme Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Transforming Molecular Synthesis With Large Language Models.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Quantifying the failure modes of current one-step retrosynthesis models.Chemical science · 2026Article
- High yield strategies for triterpenoid biosynthesis in cell factories.Journal of microbiology (Seoul, Korea) · 2026Review
- A general-purpose framework for chemical reaction representation with atomic correspondence and flexible condition adaptation.Journal of cheminformatics · 2026Article
- Target discovery and drug design in the era of artificial intelligence.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Review
- Higher-Level Strategies for Computer-Aided Retrosynthesis.ACS central science · 2026Article
- Design and Experimental Validation of a Photocatalyst Recommender Based on a Large Language Model.Angewandte Chemie (International ed. in English) · 2026Article
- A virtual platform for automated hybrid organic-enzymatic synthesis planning.Nature communications · 2025Article
- Data-driven recommendation of agents, temperature, and equivalence ratios for organic synthesis.Chemical science · 2025Article
- MolPrice: assessing synthetic accessibility of molecules based on market value.Journal of cheminformatics · 2025Article
- The Promise and Pitfalls of Artificial Intelligence in the Evaluation of Synthetic "Greenness".ChemSusChem · 2025Article
- Synergizing a knowledge graph and large language model for relay catalysis pathway recommendation.National science review · 2025Article
- Atom-by-Atom Iterative Synthetic Logic: Laying the Foundation for Programmable Automated Construction of Small Organic Molecules.ACS central science · 2025Review
- Cross-disciplinary perspectives on the potential for artificial intelligence across chemistry.Chemical Society reviews · 2025Review
- ASKCOS: Open-Source, Data-Driven Synthesis Planning.Accounts of chemical research · 2025Article
- Computer-Generated, Mechanistic Networks Assist in Assigning the Outcomes of Complex Multicomponent Reactions.Journal of the American Chemical Society · 2025Article
- Syn-MolOpt: a synthesis planning-driven molecular optimization method using data-derived functional reaction templates.Journal of cheminformatics · 2025Article
- Intelligent design and synthesis of energy catalytic materials.Fundamental research · 2025Review
- Artificial Intelligence in Natural Product Drug Discovery: Current Applications and Future Perspectives.Journal of medicinal chemistry · 2025Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Training algorithms to computationally plan multistep organic syntheses has been a challenge for more than 50 years
Indexed as
Identifiers
33049755What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.