Evidence map›Paper›PMID 33049680›Full record

ReviewFrontiers in bioscience (Landmark edition)2021

Optimum health and inhibition of cancer progression by microbiome and resveratrol.

James Stokes Iii, Sankalp Vinayak, Jazalyn Williams, Shalie Malik, Rajesh Singh, Upender Manne, Taofeek K Owonikoko, Manoj K Mishra

Open access · greenAbstract readReview
In one paragraph

Review in Frontiers in bioscience (Landmark edition), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

James Stokes IiiCancer Biology Research and Training Program, Department of Biological Sciences, Alabama State University, AL 36101.
Sankalp VinayakCancer Biology Research and Training Program, Department of Biological Sciences, Alabama State University, AL 36101.
Jazalyn WilliamsCancer Biology Research and Training Program, Department of Biological Sciences, Alabama State University, AL 36101.
Shalie MalikDepartment of Zoology, University of Lucknow, Lucknow, 226007, India.
Rajesh SinghDepartment of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA, 30310.
Upender ManneDepartment of Pathology, University of Alabama Birmingham, Birmingham, AL 35294.
Taofeek K OwonikokoHematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322.
Manoj K MishraCancer Biology Research and Training Program, Department of Biological Sciences, Alabama State University, AL 36101.
Alabama State University · US

Funding

Intersection of Social Capital, Mentorship and Networking on Persistence, Engagement and Science IdentityU01GM132769 · NIGMS · ALABAMA STATE UNIVERSITY · PI MISHRA, MANOJ K. · 2019 to 2023
$3.0M
Training and Education ProgramP20CA192973 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MANNE, UPENDER · 2014 to 2017
$767k
Project 2: 2/2 The Alabama State University/UAB Comprehensive Cancer Center PartnershipP20CA192976 · NCI · ALABAMA STATE UNIVERSITY · PI SCISSUM GUNN, KARYN D · 2014 to 2017
$598k
NCI NIH HHS P20 CA192973NCI NIH HHS P20 CA192976NIGMS NIH HHS U01 GM132769
6 · The paper itself

Abstract

Resveratrol (RES) is a naturally occurring polyphenol found in fruits, green leafy vegetables, and peanuts. This versatile compound, which has potent regenerative, anti-oxidative, and cancer-fighting properties, is produced in plants, particularly in response to stress stimuli. By various mechanisms, including regulation of genes and proteins, RES inhibits the growth of pathogenic bacteria and the development of cancers. The gut has a prominent role in nutrient assimilation, metabolism, immunity, and cancer regression, and the endogenous microbiome protects the host from invasive bacteria that facilitate the progression of various diseases. Short-chain fatty acids (SFCAs) are the byproducts of microbial fermentation in the gastrointestinal tract. Native microflora regulates internal homeostasis, influence the activity of host immune cells, and regress some cancers via the action of SCFAs produced from a plant-based diet. This review shows the relevance of dietary constituents and gut microbial activity in ensuring optimal health of the host.

Indexed as

AntioxidantsDisease ProgressionGastrointestinal MicrobiomeHumansNeoplasmsResveratrolAntioxidantsResveratrol

Identifiers

PMID33049680
PMCPMC8627189
OpenAlexW3092064841

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.