Evidence map›Paper›PMID 33049619›Full record

ArticleJournal of the mechanical behavior of biomedical materials2021

The heterogeneous morphology of networked collagen in distal colon and rectum of mice quantified via nonlinear microscopy.

Franz Maier, Saeed Siri, Stephany Santos, Longtu Chen, Bin Feng, David M Pierce

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Morphological and Functional Colonic Defects Caused by a Mutated Thyroid Hormone Receptor α.Thyroid : official journal of the American Thyroid Association · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Optical clearing reveals TNBS-induced morphological changes of VGLUT2-positive nerve fibers in mouse colorectum.American journal of physiology. Gastrointestinal and liver physiology · 2021
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Franz MaierDepartment of Mechanical Engineering, University of Connecticut, CT, 06269, USA.
Saeed SiriDepartment of Biomedical Engineering, University of Connecticut, CT, 06269, USA.
Stephany SantosDepartment of Biomedical Engineering, University of Connecticut, CT, 06269, USA.
Longtu ChenDepartment of Biomedical Engineering, University of Connecticut, CT, 06269, USA.
Bin FengDepartment of Biomedical Engineering, University of Connecticut, CT, 06269, USA. Electronic address: fengb@uconn.edu.
David M PierceDepartment of Mechanical Engineering, University of Connecticut, CT, 06269, USA; Department of Biomedical Engineering, University of Connecticut, CT, 06269, USA. Electronic address: david.pierce@uconn.edu.
University of Connecticut · US

Funding

Determining the topology and molecular profiles of nociceptive DRG neurons innervating distal colon and rectumU01NS113873 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI FENG, BIN · 2019 to 2021
$2.0M
The Role of Lumbar Splanchnic Innervations in Visceral Nociception and PainR01DK120824 · NIDDK · UNIVERSITY OF CONNECTICUT STORRS · PI FENG, BIN · 2019 to 2023
$2.0M
NIDDK NIH HHS R01 DK120824NINDS NIH HHS U01 NS113873
6 · The paper itself

Abstract

Visceral pain from the distal colon and rectum (colorectum) is a major complaint of patients with irritable bowel syndrome. Mechanotransduction of colorectal distension/stretch appears to play a critical role in visceral nociception, and further understanding requires improved knowledge of the micromechanical environments at different sub-layers of the colorectum. In this study, we conducted nonlinear imaging via second harmonic generation to quantify the thickness of each distinct through-thickness layer of the colorectum, as well as the principal orientations, corresponding dispersions in orientations, and the distributions of diameters of collagen fibers within each of these layers. From C57BL/6 mice of both sexes (8-16 weeks of age, 25-35 g), we dissected the distal 30 mm of the large bowel including the colorectum, divided these into three even segments, and harvested specimens (~8 × 8 mm

Indexed as

CollagenColonMechanotransduction, CellularRectumAnimalsFemaleMaleMiceMice, Inbred C57BLMicroscopyCollagenBiaxial extension testColorectumConfocal microscopyMechanotransductionSubmucosaVisceral pain

Identifiers

PMID33049619
PMCPMC7725919
OpenAlexW3092149151

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.