ArticleRedox biology2020
SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy.
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Article in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
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Who cites it
53 citing papers in PubMed, 80 citations in OpenAlex.
- The Gut-Brain Axis: A Critical Link between Type 2 Diabetes and Parkinson's disease.Probiotics and antimicrobial proteins · 2026Review
- Identification of a Lactylation-Related Gene Signature and Candidate Biomarkers for Dilated Cardiomyopathy.Journal of cellular and molecular medicine · 2026Article
- Mitochondrial Distress Signals at the Heart-Liver Interface: Molecular Links Between MASLD and Heart Failure.International journal of molecular sciences · 2026Review
- Mitochondrial vulnerability to aldehydic load and the role mitochondrial aldehyde dehydrogenases.Pharmacological research · 2026Review
- SOD2-Superoxide Metabolic Axis Regulates Mitophagy and Modulates TKIs Sensitivity in Head and Neck Squamous Cell Carcinoma.Cancer science · 2026Article
- Chemo-/radiotherapy-induced cardiomyopathy: roles of mitochondria and endoplasmic reticulum.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Review
- An integrative approach to identify novel miRNA-mRNA interaction networks in LMNA-cardiomyopathy.Scientific reports · 2026Article
- Hypoxia, ROS, and HIF Signaling in I/R Injury: Implications and Future Prospects.Antioxidants (Basel, Switzerland) · 2026Review
- Identification and analysis of diagnostic senescence-related gene signatures for acute myocardial infarction based on multi-omics data and machine learning.Frontiers in immunology · 2026Article
- Ameliorative effects of aFrontiers in pharmacology · 2026Article
- Mitochondria-Targeted Antioxidants Prevent Tachypacing-Induced Contractile Dysfunction in In Vitro Cardiomyocyte and In VivoAntioxidants (Basel, Switzerland) · 2025Article
- Histone H3 Lysine 18 Lactylation Promotes Cardiac Hypertrophy Through Activating GATA Binding Protein 4 Signaling.MedComm · 2025Article
- Metabolic Disturbances Involved in Cardiovascular Diseases: The Role of Mitochondrial Dysfunction, Altered Bioenergetics and Oxidative Stress.International journal of molecular sciences · 2025Review
- Involvement of Oxidative Stress in Mitochondrial Abnormalities During the Development of Heart Disease.Biomedicines · 2025Review
- Hypertrophic Cardiomyopathy Through the Lens of Mitochondria.Biomedicines · 2025Review
- Neonatally-derived multipotent Islet-1+ Mesp1+FOXA2+ stem cell clones restore cardiac function in sheep.Frontiers in cardiovascular medicine · 2025Article
- Melatonin Exerts Positive Effects on Sepsis Through Various Beneficial Mechanisms.Drug design, development and therapy · 2025Review
- To Explore the Mechanism of Cuproptosis in Psoriasis Based on Bioinformatics and in vivo Experiments.Journal of inflammation research · 2025Article
- Article
- Targeting DNM1L/DRP1-FIS1 axis inhibits high-grade glioma progression by impeding mitochondrial respiratory cristae remodeling.Journal of experimental & clinical cancer research : CR · 2024Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Sudha SharmaDepartment of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Susmita BhattaraiDepartment of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Hosne AraDepartment of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Grace SunDepartment of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Daret K St ClairDepartment of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, USA.
Md Shenuarin BhuiyanDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Christopher KevilDepartment of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Megan N WattsDivision of Cardiology, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Paari DominicDivision of Cardiology, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Takahiko ShimizuNational Center for Geriatrics and Gerontology, 7-430, Morioka, Obu Aichi, Japan.
Kevin J McCarthyDepartment of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Hong SunDepartment of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Manikandan PanchatcharamDepartment of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA. Electronic address: mpanch@lsuhsc.edu.
Sumitra MiriyalaDepartment of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA. Electronic address: smiriy@lsuhsc.edu.
Louisiana State University Health Sciences Center Shreveport · USNational Center for Geriatrics and Gerontology · JPUniversity of Kentucky · US
Funding
Stress Exacerbates Myocardial Ischemic Injury by Blocking Estrogen's Antidoxidant Protection in the Female HeartP20GM121307 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Christopher G Kevil · 2018 to 2026
$23.6MThe role ofglycosaminoglycan N-sulfation in glomerular biology/pathobiologyR01DK111958 · NIDDK · LOUISIANA STATE UNIV HSC SHREVEPORT · PI MCCARTHY, KEVIN JOHN · 2017 to 2021
$2.6MSigmar1 in lipid metabolismR01HL145753 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI BHUIYAN, MD. SHENUARIN · 2019 to 2023
$2.6MCSE regulation of vascular remodelingR01HL149264 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI KEVIL, CHRISTOPHER G · 2020 to 2023
$1.7MSigma-1 receptor and cardioprotectionR00HL122354 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI BHUIYAN, MD. SHENUARIN · 2015 to 2017
$747kPrenatal ethanol mediated regulation of bioactive lipid: Role of Autotaxin and LPP3 in Alzheimer disease.R15HL141998 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI MIRIYALA, SUMITRA · 2018 to 2019
$508kAlcohol-LPP3 axis in ischemic strokeR21AA025744 · NIAAA · LOUISIANA STATE UNIV HSC SHREVEPORT · PI PANCHATCHARAM, MANIKANDAN · 2017 to 2018
$483kAlcohol mediated myocardial lysophosphatidic acid signalingR21AA026708 · NIAAA · LOUISIANA STATE UNIV HSC SHREVEPORT · PI PANCHATCHARAM, MANIKANDAN · 2020 to 2021
$383kNHLBI NIH HHS R00 HL122354NHLBI NIH HHS R01 HL145753NHLBI NIH HHS R01 HL149264NHLBI NIH HHS R15 HL141998NIAAA NIH HHS R21 AA025744NIAAA NIH HHS R21 AA026708NIDDK NIH HHS R01 DK111958NIGMS NIH HHS P20 GM121307
Abstract
Electrophilic aldehyde (4-hydroxynonenal; 4-HNE), formed after lipid peroxidation, is a mediator of mitochondrial dysfunction and implicated in both the pathogenesis and the progression of cardiovascular disease. Manganese superoxide dismutase (MnSOD), a nuclear-encoded antioxidant enzyme, catalyzes the dismutation of superoxide radicals (O
Indexed as
Cardiomyopathy, DilatedMitochondriaAnimalsMiceMice, KnockoutMyocytes, CardiacOxidative PhosphorylationOxidative StressReactive Oxygen SpeciesSuperoxide DismutaseSuperoxide Dismutase 2Reactive Oxygen SpeciesSuperoxide DismutaseSuperoxide Dismutase 2Heart failureManganese superoxide dismutaseSuperoxide radicals
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What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.