ArticleJournal of critical care2021
Safety and efficacy of vasopressor administration through midline catheters.
Article in Journal of critical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Análisis de la utilización de Los catéteres Intravenosos periféricos de Linea Media Frente a Los catéteres Intravenosos periféricos Convencionales en el Servicio de Medicina Interna
Application Study of Infusing Irritant Medications Through Midline Catheter Based on Real World Study
Superior Ultrasound-Guided Venous Access: Single-Lumen Midline Catheters vs Long Peripheral IVs for Difficult IV Access in the Emergency Department, A Randomized Controlled Trial
Superior Venous Access: Single Lumen Midline Catheter vs Ultrasound Guided Peripheral IV as Performed by Bedside Emergency Department Registered Nurses, A Randomized Clinical Trial
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Incidence of Adverse Events in Peripheral Intravenous Vasopressor Use: A Systematic Review and Meta-Analysis.JAMA network open · 2026Pooled it
- A Meta-Analysis of Incidence of Catheter-Related Bloodstream Infection with Midline Catheters and Peripherally Inserted Central Catheters.Journal of healthcare engineering · 2022Pooled it
- Comparison of the effects of mini-midline catheter placement in the forearm versus upper arm of neurosurgical patients based on propensity score matching.BMC neurology · 2026Observational
- Midline Catheters: A Novel Curriculum for Emergency Medicine Residents.Journal of education & teaching in emergency medicine · 2026Article
- Utility of a Peripheral Intravenous Catheter for Administration of Vasopressors: A Narrative Review.Cureus · 2026Review
- Use of preoperative placement of mini-midline catheters in patients undergoing thoracoscopic lung resection.Scientific reports · 2026Article
- Article
- Extravasation, thrombosis, and infection with vasopressor infusion through peripheral intravenous catheters: a systematic review and meta-analysis.Cardiovascular diagnosis and therapy · 2025Article
- Safety and efficacy of a new long peripheral catheter in hospitalized patients - a retrospective observational study.SAGE open medicine · 2025Article
- Treating shock with norepinephrine administered in midline catheters in an intermediary care unit: a retrospective cohort study.BMJ open · 2024Observational
- Evaluation of the safety and efficacy of peripheral vasopressors to decrease central line placement and associated bloodstream infections.Journal of infection prevention · 2024Article
- Safety and efficacy of peripheral metaraminol infusion in patients with neurological conditions: a single-center retrospective observational study.Frontiers in neurology · 2024Article
- Comparison of complication types in patients receiving vesicant intravenous antimicrobials or vasopressors via midlines and peripherally inserted central catheters.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- The Association of Vasopressor Administration through a Midline Catheter with Catheter-related Complications.Annals of the American Thoracic Society · 2023Article
- Usefulness of Midline Catheters versus Peripheral Venous Catheters in an Inpatient Unit: A Pilot Randomized Clinical Trial.Nursing reports (Pavia, Italy) · 2022Article
- The midline venous catheter in critically ill COVID-19 patients.Medicina intensiva · 2022Article
- Evaluation of the safety of a novel peripheral vasopressor pilot program and the impact on central line placement in medical and surgical intensive care units.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextVasopressors are commonly administered through Central Venous Catheters (CVCs) as it is considered unsafe to administer them via peripheral IVs, mainly due to the concern of local tissue injury. Unlike peripheral IVs, midline catheters provide a wider lumen with the catheter tip ending in a large peripheral vein. The use of vasopressors through midline catheters has not yet been evaluated.
objectiveThe primary objective of this study is to determine the safety and efficacy of long term administration of vasopressors through a midline catheter.
designThis is a retrospective study between 2016 and 2019 looking at the outcomes of midline catheters.
setting45 bed Tertiary level ICU in a 600-bed teaching hospital. PATIENTS: A total of 248 patients received vasopressors via midline catheters.
resultsThe average midline dwell time was 14.7 ± 12.8 days and the average duration of continuous vasopressor infusion was 7.8 ± 9.3 days. Vasopressors used with their average dose (AD) were norepinephrine (n = 165, 16.8 CE ± 10.7 μg/min), epinephrine (n = 56, 9.1 CE ± 6.0 μg/min), vasopressin (n = 123, 0.05 CE ± 0.02 units/min), phenylephrine (n = 158, 91.4 CE ± 64.7 μg/min) and Angiotensin II (50 CE ± 27.6 ng/kg/min). Early Complication rate was 3.6% due to Bloodstream infection (n = 6), drug extravasation (n = 1), thrombophlebitis (n = 1) and arterial puncture (n = 1). Late Complication rate was 0.8% (n = 2) due to midline-associated DVTs. There were no complications related to ineffective drug delivery or limb endangerment.
conclusionsMany medical centers are attempting to limit the use of central venous catheters (CVCs) to avoid central line-associated bloodstream infections (CLABSIs). This study demonstrates that midline catheters are a safe alternative to CVCs, for the safe and efficacious administration of vasopressors for prolonged periods of time.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.