Evidence map›Paper›PMID 33049206›Full record

ArticleCancer cell2020

Cholesterol Biosynthesis Influences Subtype Specificity and Plasticity in Pancreas Cancer.

Sita Kugel, Sunil R Hingorani

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. PrPInternational journal of biological sciences · 2022
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sita KugelHuman Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: skugel@fredhutch.org.
Sunil R HingoraniClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Medical Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA. Electronic address: srh@fredhutch.org.
Fred Hutch Cancer Center · USUniversity of Washington Medical Center · US

Funding

OVERCOMING STROMAL BARRIERS TO THERAPEUTICS IN PANCREAS CANCERR01CA161112 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Sunil R Hingorani · 2011 to 2026
$7.6M
Exploring the epigenetic control of pancreatic cancer subtypesR37CA241472 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KUGEL, SITA · 2019 to 2025
$2.8M
Investigating the metastatic drive in pancreas cancerR01CA223483 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HINGORANI, SUNIL R · 2018 to 2022
$2.4M
NCI NIH HHS R01 CA161112NCI NIH HHS R01 CA223483NCI NIH HHS R37 CA241472
6 · The paper itself

Abstract

Cellular plasticity contributes to intratumoral heterogeneity, metastatic spread, and treatment resistance of cancers. In this issue of Cancer Cell, Gabitova-Cornell et al. identify the potential to inadvertently develop an undifferentiated and more aggressive pancreas cancer with agents commonly prescribed to manage heart disease risk.

Indexed as

Pancreatic NeoplasmsCell DifferentiationCell PlasticityCholesterolHumansTransforming Growth Factor betaCholesterolTransforming Growth Factor beta

Identifiers

PMID33049206
PMCPMC9976615
OpenAlexW3092374528

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.