ArticleAging cell2020
Age-induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge.
Open access · goldAbstract read
In one paragraph
Article in Aging cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 10 citations in OpenAlex.
- Accumulated mtDNA mutations are linked to specific impairments in NADH-linked respiration.iScience · 2026Article
- Effect of Denervation on Skeletal Muscle Mitochondria in Heterozygous mtDNA Mutator Mice.FASEB bioAdvances · 2026Article
- DNA Polymerase Gamma Acetylation Governs Mitochondrial Homeostasis and Vascular Cell Senescence.International journal of biological sciences · 2026Article
- The nuclear and mitochondrial genomes need to tango. How is their dance synchronized during development?NAR molecular medicine · 2026Article
- Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.International journal of molecular sciences · 2025Review
- Article
- The role of mtDNA in oocyte quality and embryo development.Molecular reproduction and development · 2023Review
- Outlook of PINK1/Parkin signaling in molecular etiology of Parkinson's disease, with insights intoZoological research · 2023Review
- DNA Polymerase Gamma Recovers Mitochondrial Function and Inhibits Vascular Calcification by Interacted with p53.International journal of biological sciences · 2022Article
- Age-associated global DNA hypermethylation augments the sensitivity of hearts towards ischemia-reperfusion injury.Frontiers in genetics · 2022Article
- Age-induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge.Aging cell · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 2 institutions in 1 country.
Timothy M MooreDepartment of Biological Sciences, Dana & David Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA, USA.
Zhenqi ZhouDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Alexander R StrumwasserDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Whitaker CohnDepartment of Psychiatry and Biobehavioral Sciences & The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
Amanda J LinDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Kevin CoryDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Kate WhitneyDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Theodore HoDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Timothy HoDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Joseph L LeeDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Daniel H RuckerDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Austin N HoangDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Kevin WidjajaDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Aaron D AbrishamiDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Sarada CharugundlaDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Linsey StilesDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Julian P WhiteleggeDepartment of Psychiatry and Biobehavioral Sciences & The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
Lorraine P TurcotteDepartment of Biological Sciences, Dana & David Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA, USA.
Jonathan WanagatDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID 0000-0002-8460-8616
Andrea L HevenerDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID 0000-0003-1508-4377
University of California, Los Angeles · USUniversity of Southern California · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MTraining and education CoreU54AR052646 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MCNALLY, ELIZABETH M, SWEENEY, H LEE · 2005 to 2020
$24.1MUCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 2006 to 2017
$9.8MEXPANSION OF NURSA TRANSCRIPTOMINE ANNOTATIONU24DK097748 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI EVANS, RONALD M, MCKENNA, NEIL · 2012 to 2017
$9.2MSex Differences in the Metabolic SyndromeU54DK120342 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 2018 to 2022
$7.6MUCLA Medical Genetics Training ProgramT32GM008243 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Julian Martinez-Agosto, STANLEY F. NELSON · 1987 to 2026
$6.8MMuscle Cell Biology, Pathophysiology, and TherapeuticsT32AR065972 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Rachelle Hope Crosbie, THOMAS A. RANDO · 2016 to 2026
$3.9MNeuroendocrinology, Sex Differences, and ReproductionT32HD007228 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P · 1985 to 2015
$3.9MMechanisms controlling skeletal muscle mitochondrial function and metabolic healthR01DK109724 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HEVENER, ANDREA L · 2016 to 2020
$2.4MTraining in Molecular, Cellular &Integrative PhysiologyT32GM065823 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2003 to 2017
$2.1MNCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NIAMS NIH HHS T32 AR065972NIAMS NIH HHS U54 AR052646NIA NIH HHS K02 AG059847NIA NIH HHS P30 AG028748NIA NIH HHS R01 AG055518NICHD NIH HHS T32 HD007228NIDDK NIH HHS F31 DK108657NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK109724NIDDK NIH HHS U24 DK097748NIDDK NIH HHS U54 DK120342NIGMS NIH HHS T32 GM008243NIGMS NIH HHS T32 GM065823
Abstract
Mitochondrial dysfunction is frequently associated with impairment in metabolic homeostasis and insulin action, and is thought to underlie cellular aging. However, it is unclear whether mitochondrial dysfunction is a cause or consequence of insulin resistance in humans. To determine the impact of intrinsic mitochondrial dysfunction on metabolism and insulin action, we performed comprehensive metabolic phenotyping of the polymerase gamma (PolG) D257A "mutator" mouse, a model known to accumulate supraphysiological mitochondrial DNA (mtDNA) point mutations. We utilized the heterozygous PolG mutator mouse (PolG
Indexed as
Point MutationAnimalsDiet, High-FatDisease Models, AnimalDNA, MitochondrialHomeostasisMiceMitochondria, LiverMitochondria, MuscleNutrientsStarvationDNA, MitochondrialNutrientsaginginsulin resistancemetabolismmitochondriamitochondrial DNAobesityPOLG
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.