ArticlePLoS biology2020
Neural activity during a simple reaching task in macaques is counter to gating and rebound in basal ganglia-thalamic communication.
Article in PLoS biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- A comparison of movement-related neuronal activities in cerebellar- and basal ganglia-recipient regions of the macaque thalamus.bioRxiv : the preprint server for biology · 2026Article
- Hierarchical binding of cognition to action in the human basal ganglia-thalamic circuit.bioRxiv : the preprint server for biology · 2026Article
- Entrained cortical delta-spindle activity, not periodic synchrony, prevents arousal by NREM thalamic bursts.Communications biology · 2026Article
- Movement-related activity in the internal globus pallidus of the parkinsonian macaque.Journal of neurophysiology · 2025Article
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- Detecting rhythmic spiking through the power spectra of point process model residuals.Journal of neural engineering · 2024Article
- Contributions of Basal Ganglia Circuits to Perception, Attention, and Consciousness.Journal of cognitive neuroscience · 2024Review
- Detecting rhythmic spiking through the power spectra of point process model residuals.bioRxiv : the preprint server for biology · 2024Article
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- Introducing the STReaC (Spike Train Response Classification) toolbox.Journal of neuroscience methods · 2024Article
- A neurocomputational view of the effects of Parkinson's disease on speech production.Frontiers in human neuroscience · 2024Article
- Globus pallidus internus activity increases during voluntary movement in children with dystonia.iScience · 2023Article
- Solving brain circuit function and dysfunction with computational modeling and optogenetic fMRI.Science (New York, N.Y.) · 2022Review
- Identifying control ensembles for information processing within the cortico-basal ganglia-thalamic circuit.PLoS computational biology · 2022Article
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- Neuronal Activity of Pallidal Versus Cerebellar Receiving Thalamus in Patients with Cervical Dystonia.Cerebellum (London, England) · 2021Article
- Revisiting the "Paradox of Stereotaxic Surgery": Insights Into Basal Ganglia-Thalamic Interactions.Frontiers in systems neuroscience · 2021Review
- Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Task-related activity in the ventral thalamus, a major target of basal ganglia output, is often assumed to be permitted or triggered by changes in basal ganglia activity through gating- or rebound-like mechanisms. To test those hypotheses, we sampled single-unit activity from connected basal ganglia output and thalamic nuclei (globus pallidus-internus [GPi] and ventrolateral anterior nucleus [VLa]) in monkeys performing a reaching task. Rate increases were the most common peri-movement change in both nuclei. Moreover, peri-movement changes generally began earlier in VLa than in GPi. Simultaneously recorded GPi-VLa pairs rarely showed short-time-scale spike-to-spike correlations or slow across-trials covariations, and both were equally positive and negative. Finally, spontaneous GPi bursts and pauses were both followed by small, slow reductions in VLa rate. These results appear incompatible with standard gating and rebound models. Still, gating or rebound may be possible in other physiological situations: simulations show how GPi-VLa communication can scale with GPi synchrony and GPi-to-VLa convergence, illuminating how synchrony of basal ganglia output during motor learning or in pathological conditions may render this pathway effective. Thus, in the healthy state, basal ganglia-thalamic communication during learned movement is more subtle than expected, with changes in firing rates possibly being dominated by a common external source.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.