Evidence map›Paper›PMID 33048610›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2021

Clinical Radiographic Predictors of Response to Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea.

Clara H Lee, Everett G Seay, James W Reese, Xin Wu, Richard J Schwab, Brendan Keenan, Raj C Dedhia

Abstract read
In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. [Surgical treatment of adult obstructive sleep apnea].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Hypoglossal Nerve Stimulation Therapy.Advances in experimental medicine and biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Clara H LeeDepartment of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical College, New York, New York, USA.
Everett G SeayDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
James W ReeseBaylor Radiologists: A Radiology Partners Affiliated Practice, Houston, Texas, USA.
Xin WuDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Richard J SchwabDivision of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Brendan KeenanDivision of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Raj C DedhiaDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Funding

Lingual muscle control of upper airway patency in obstructive sleep apneaR01HL144859 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DEDHIA, RAJ C., SCHWARTZ, ALAN R. · 2019 to 2023
$3.9M
NHLBI NIH HHS R01 HL144859
6 · The paper itself

Abstract

objectiveTo determine if clinically acquired cephalometric measurements, specifically soft palate size, can predict hypoglossal nerve stimulation outcomes. STUDY

designCombined prospective cohort study and retrospective review.

settingUS sleep otolaryngology training program.

methodsAdults with obstructive sleep apnea and apneahypopnea index greater than 15 events/h who underwent hypoglossal nerve stimulation. Eligible subjects had diagnostic preoperative sleep studies and full-night efficacy postoperative studies for analysis. Lateral neck x-rays were obtained as part of routine clinical care and measured for key cephalometric variables by trained head and neck radiologists. Continuous variables were compared using the Student

resultsFifty-one patients met all study criteria. On average, patients were white, middle aged, and overweight. Following hypoglossal nerve stimulation, the overall cohort achieved a significant apnea-hypopnea index reduction from 36.7 events/h to 20.6 events/h (

conclusionsPatient-specific anatomic factors, specifically soft palate thickness, may help identify optimal candidates for hypoglossal nerve stimulation. A larger, prospective study including both anatomic and physiologic variables is required to validate these findings.

Indexed as

Electric Stimulation TherapyHypoglossal NerveAgedCephalometryFemaleHumansMaleMiddle AgedOrgan SizePalate, SoftPredictive Value of TestsProspective StudiesRadiographyRetrospective StudiesSleep Apnea, ObstructiveTreatment Outcomehypoglossal nerve stimulationobstructive sleep apneaoutcomesradiograph

Identifiers

PMID33048610
PMCPMC10231400

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.