Evidence map›Paper›PMID 33048401›Full record

ArticleMagnetic resonance in medicine2021

Motion-compensated gradient waveforms for tensor-valued diffusion encoding by constrained numerical optimization.

Filip Szczepankiewicz, Jens Sjölund, Erica Dall'Armellina, Sven Plein, Jürgen E Schneider, Irvin Teh, Carl-Fredrik Westin

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
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  5. Engineering clinical translation of OGSE diffusion MRI.Magnetic resonance in medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Filip SzczepankiewiczHarvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-5251-587X
Jens SjölundElekta Instrument AB, Stockholm, Sweden.
Erica Dall'ArmellinaLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom.
Sven PleinLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom.
Jürgen E SchneiderLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom.
Irvin TehLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom.ORCID 0000-0002-6705-3129
Carl-Fredrik WestinHarvard Medical School, Boston, Massachusetts, USA.

Funding

Training and DisseminationP41EB015902 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON, WESTIN, CARL-FREDRIK · 2012 to 2022
$20.9M
Novel DT-MRI Analyses of White Matter in SchizophreniaR01MH074794 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI WESTIN, CARL-FREDRIK · 2007 to 2021
$9.6M
British Heart Foundation FS/13/71/30378British Heart Foundation PG/19/1/34076British Heart Foundation SI/14/1/30718NIBIB NIH HHS P41 EB015902NIMH NIH HHS R01 MH074794
6 · The paper itself

Abstract

purposeDiffusion-weighted MRI is sensitive to incoherent tissue motion, which may confound the measured signal and subsequent analysis. We propose a "motion-compensated" gradient waveform design for tensor-valued diffusion encoding that negates the effects bulk motion and incoherent motion in the ballistic regime.

methodsMotion compensation was achieved by constraining the magnitude of gradient waveform moment vectors. The constraint was incorporated into a numerical optimization framework, along with existing constraints that account for b-tensor shape, hardware restrictions, and concomitant field gradients. We evaluated the efficacy of encoding and motion compensation in simulations, and we demonstrated the approach by linear and planar b-tensor encoding in a healthy heart in vivo.

resultsThe optimization framework produced asymmetric motion-compensated waveforms that yielded b-tensors of arbitrary shape with improved efficiency compared with previous designs for tensor-valued encoding, and equivalent efficiency to previous designs for linear (conventional) encoding. Technical feasibility was demonstrated in the heart in vivo, showing vastly improved data quality when using motion compensation. The optimization framework is available online in open source.

conclusionOur gradient waveform design is both more flexible and efficient than previous methods, facilitating tensor-valued diffusion encoding in tissues in which motion would otherwise confound the signal. The proposed design exploits asymmetric encoding times, a single refocusing pulse or multiple refocusing pulses, and integrates compensation for concomitant gradient effects throughout the imaging volume.

Indexed as

Diffusion Magnetic Resonance ImagingImage Processing, Computer-AssistedDiffusionHeartMotiondiffusion magnetic resonance imaginggradient waveform designmotion and flow compensationtensor-valued diffusion encoding

Identifiers

PMID33048401
PMCPMC7821235

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