ReviewCerebellum (London, England)2021
Increased Purkinje Cell Complex Spike and Deep Cerebellar Nucleus Synchrony as a Potential Basis for Syndromic Essential Tremor. A Review and Synthesis of the Literature.
Review in Cerebellum (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Meta-analysis and open-source database for in vivo brain Magnetic Resonance spectroscopy in health and disease.Analytical biochemistry · 2023Pooled it
- Pathophysiology of Cerebellar Tremor: The Forward Model-Related Tremor and the Inferior Olive Oscillation-Related Tremor.Frontiers in neurology · 2021Pooled it
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- The cerebellum shapes motions by encoding motor frequencies with precision and cross-individual uniformity.Nature biomedical engineering · 2025Article
- A Role for GABATremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Six Myths and Misconceptions about Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Review
- Article
- Meta-analysis and Open-source Database for In Vivo Brain Magnetic Resonance Spectroscopy in Health and Disease.bioRxiv : the preprint server for biology · 2023Article
- Cerebellar α6GABANeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Chemical suppression of harmaline-induced body tremor yields recovery of pairwise neuronal coherence in cerebellar nuclei neurons.Frontiers in systems neuroscience · 2023Article
- Alcohol and Ganaxolone Suppress Tremor via Extra-Synaptic GABATremor and other hyperkinetic movements (New York, N.Y.) · 2023Article
- Search for Novel Therapies for Essential Tremor Based on Positive Modulation of α6-Containing GABATremor and other hyperkinetic movements (New York, N.Y.) · 2023Article
- Cerebellar dysfunction in rodent models with dystonia, tremor, and ataxia.Dystonia (Lausanne, Switzerland) · 2023Article
- Article
- Reclassification of patients with tremor syndrome and comparisons of essential tremor and essential tremor-plus patients.Journal of neurology · 2022Observational
- Is the inferior olive central to essential tremor? Yes.International review of neurobiology · 2022Article
- Is essential tremor a disorder of primary GABA dysfunction? Yes.International review of neurobiology · 2022Review
- How important is the inferior olive in essential tremor? An evolving story.International review of neurobiology · 2022Article
- The Pathophysiology and Treatment of Essential Tremor: The Role of Adenosine and Dopamine Receptors in Animal Models.Biomolecules · 2021Review
- Cerebellar nuclei neurons display aberrant oscillations during harmaline-induced tremor.Heliyon · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
We review advances in understanding Purkinje cell (PC) complex spike (CS) physiology that suggest increased CS synchrony underlies syndromic essential tremor (ET). We searched PubMed for papers describing factors that affect CS synchrony or cerebellar circuits potentially related to tremor. Inferior olivary (IO) neurons are electrically coupled, with the degree of coupling controlled by excitatory and GABAergic inputs. Clusters of coupled IO neurons synchronize CSs within parasagittal bands via climbing fibers (Cfs). When motor cortex is stimulated in rats at varying frequencies, whisker movement occurs at ~10 Hz, correlated with synchronous CSs, indicating that the IO/CS oscillatory rhythm gates movement frequency. Intra-IO injection of the GABA
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.