ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021
Association of lipid profiles with severity and outcome of acute ischemic stroke in patients with and without chronic kidney disease.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Association between lipid profiles and early clinical outcomes in acute ischemic stroke: a single-center cohort study in the Chinese population.BMC neurology · 2025Article
- Investigating the impact of glycated hemoglobin levels on stroke severity in patients with acute ischemic stroke.Scientific reports · 2025Article
- Associations of triglyceride glucose-body mass index with short-term mortality in critically ill patients with ischemic stroke.Cardiovascular diabetology · 2025Article
- Epidemiology and Risk Factors for Stroke in Chronic Kidney Disease: A Narrative Review.Biomedicines · 2023Review
- Gomisin J attenuates cerebral ischemia/reperfusion injury by inducing anti-apoptotic, anti-inflammatory, and antioxidant effects in rats.Bioengineered · 2022Article
- Gut microbiota signature as predictors of adverse outcomes after acute ischemic stroke in patients with hyperlipidemia.Frontiers in cellular and infection microbiology · 2022Article
- Association of HbA1c and comorbidities on stroke severity: insights from a cross-sectional analysis in a tertiary hospital.Frontiers in neurologyArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundContribution of lipid profiles to stroke severity and outcome was inconclusive, whether chronic kidney disease (CKD) (estimated glomerular filtration rate < 60 mL/min/1.73 m
methodsA retrospective study of consecutive acute ischemic stroke patients was performed. We assessed the risk of severe stroke with the National Institutes of Health Stroke Scale (NIHSS) ≥ 5 at admission and poor outcome with the modified Rankin Scale (mRS) ≥ 3 at discharge. Multivariate stepwise logistic regression models were adopted to study interaction and independent association of lipid components with stroke severity and outcome according to lipid level quartiles by CKD stratification.
resultsAmong the 875 included patients (mean age 64.9 years, 67.8% males), 213 (24.3%) presented with CKD. Elevated low-density lipoprotein cholesterol (LDL-C) was independently associated with severe stroke in patients with CKD (P for trend = 0.033) than in those without CKD (P for trend = 0.121). The association between the level of LDL-C and stroke severity was appreciably modified by CKD (P
conclusionLDL-C levels are positively associated with stroke severity in only patients with CKD, with an interactive impact of LDL-C and CKD on ischemic stroke in the acute phase.
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