Evidence map›Paper›PMID 33048195›Full record

Trial reportIntensive care medicine2021

Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial.

K Baksaas-Aasen, L S Gall, J Stensballe, N P Juffermans, N Curry, M Maegele, A Brooks, C Rourke, S Gillespie, J Murphy and 17 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Intensive care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed, 10 pooled it
19.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 10 syntheses or guidelines pooled it, 300 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Blood transfusion strategies for major bleeding in trauma.The Cochrane database of systematic reviews · 2025
    Pooled it
  4. Guideline
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  8. Guideline
  9. Pooled it
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  11. Trial
  12. Trial
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  14. Article
  15. Review
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  18. Article
  19. From single to dual platelet inhibition FIBTEM assay: fibrinogen replacement thresholds for critical bleeding after trauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Article
  20. Article

68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 9 institutions in 5 countries.

K Baksaas-AasenOslo University Hospital & University of Oslo, Oslo, Norway.
L S GallCentre for Trauma Sciences, Queen Mary University of London, Blizard Institute, 4 Newark Street, London, E1 2AT, UK.
J StensballeCopenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
N P JuffermansAmsterdam University Medical Centres, Amsterdam, The Netherlands.
N CurryOxford University Hospital NHS Trust, Oxford, UK.
M MaegeleCologne-Merheim Medical Centre, University of Witten/Herdecke, Cologne, Germany.
A BrooksNottingham University Hospitals NHS Trust, Nottingham, UK.
C RourkeCentre for Trauma Sciences, Queen Mary University of London, Blizard Institute, 4 Newark Street, London, E1 2AT, UK.
S GillespieCentre for Trauma Sciences, Queen Mary University of London, Blizard Institute, 4 Newark Street, London, E1 2AT, UK.
J MurphyQueen Mary University of London, London, UK.
R MaroniQueen Mary University of London, London, UK.
P VulliamyCentre for Trauma Sciences, Queen Mary University of London, Blizard Institute, 4 Newark Street, London, E1 2AT, UK.
H H HenriksenCopenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
K Holst PedersenCopenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
K M KolstadbraatenOslo University Hospital & University of Oslo, Oslo, Norway.
M R WirtzAmsterdam University Medical Centres, Amsterdam, The Netherlands.
D J B KleinveldAmsterdam University Medical Centres, Amsterdam, The Netherlands.
N SchäferCologne-Merheim Medical Centre, University of Witten/Herdecke, Cologne, Germany.
S ChinnaNottingham University Hospitals NHS Trust, Nottingham, UK.
R A DavenportCentre for Trauma Sciences, Queen Mary University of London, Blizard Institute, 4 Newark Street, London, E1 2AT, UK.
P A NaessOslo University Hospital & University of Oslo, Oslo, Norway.
J C GoslingsAmsterdam University Medical Centres, Amsterdam, The Netherlands.
S EaglestoneCentre for Trauma Sciences, Queen Mary University of London, Blizard Institute, 4 Newark Street, London, E1 2AT, UK.
S StanworthOxford University Hospital NHS Trust, Oxford, UK.
P I JohanssonCopenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
C GaarderOslo University Hospital & University of Oslo, Oslo, Norway.
K BrohiCentre for Trauma Sciences, Queen Mary University of London, Blizard Institute, 4 Newark Street, London, E1 2AT, UK. k.brohi@qmul.ac.uk.
Queen Mary University of London · GBAmsterdam University Medical Centers · NLOslo University Hospital · NORigshospitalet · DKNottingham University Hospitals NHS Trust · GBOxford University Hospitals NHS Trust · GBWitten/Herdecke University · DECopenhagen University Hospital · DKUniversity of Oslo · NO

Funding

Seventh Framework Programme F3-2013-602771
6 · The paper itself

Abstract

purposeContemporary trauma resuscitation prioritizes control of bleeding and uses major haemorrhage protocols (MHPs) to prevent and treat coagulopathy. We aimed to determine whether augmenting MHPs with Viscoelastic Haemostatic Assays (VHA) would improve outcomes compared to Conventional Coagulation Tests (CCTs).

methodsThis was a multi-centre, randomized controlled trial comparing outcomes in trauma patients who received empiric MHPs, augmented by either VHA or CCT-guided interventions. Primary outcome was the proportion of subjects who, at 24 h after injury, were alive and free of massive transfusion (10 or more red cell transfusions). Secondary outcomes included 28-day mortality. Pre-specified subgroups included patients with severe traumatic brain injury (TBI).

resultsOf 396 patients in the intention to treat analysis, 201 were allocated to VHA and 195 to CCT-guided therapy. At 24 h, there was no difference in the proportion of patients who were alive and free of massive transfusion (VHA: 67%, CCT: 64%, OR 1.15, 95% CI 0.76-1.73). 28-day mortality was not different overall (VHA: 25%, CCT: 28%, OR 0.84, 95% CI 0.54-1.31), nor were there differences in other secondary outcomes or serious adverse events. In pre-specified subgroups, there were no differences in primary outcomes. In the pre-specified subgroup of 74 patients with TBI, 64% were alive and free of massive transfusion at 24 h compared to 46% in the CCT arm (OR 2.12, 95% CI 0.84-5.34).

conclusionThere was no difference in overall outcomes between VHA- and CCT-augmented-major haemorrhage protocols.

Indexed as

Blood Coagulation DisordersHemostaticsWounds and InjuriesHemorrhageHemostasisHumansMulticenter Studies as TopicThrombelastographyHemostaticsCoagulopathyHaemorrhageThrombelastographyThromboelastometryTrauma

Identifiers

PMID33048195
PMCPMC7550843
OpenAlexW3092224221

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.