Evidence map›Paper›PMID 33047894›Full record

ArticleCNS neuroscience & therapeutics2021

Evaluation of diagnostic criteria and red flags of myelin oligodendrocyte glycoprotein encephalomyelitis in a clinical routine cohort.

Krenar Veselaj, Nicole Kamber, Myriam Briner, Christoph Friedli, Lara Diem, Kirsten Guse, Andrei Miclea, Roland Wiest, Franca Wagner, Hilary Grabe and 6 more

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Krenar VeselajDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Nicole KamberDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Myriam BrinerDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Christoph FriedliDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Lara DiemDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Kirsten GuseDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Andrei MicleaDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Roland WiestDepartment of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Franca WagnerDepartment of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Hilary GrabeDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Mathias AbeggDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Michael P HornDepartment of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Sandra BigiDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Andrew ChanDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Robert HoepnerDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-0115-7021
Anke SalmenDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-4751-299X
University of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsMyelin oligodendrocyte glycoprotein antibodies (MOG-IgG) have been proposed to define "MOG encephalomyelitis" (MOG-EM), with published diagnostic and "red flag" criteria. We aimed to evaluate these criteria in a routine clinical setting.

methodsWe retrospectively analyzed patients with borderline/positive MOG-IgG and applied the diagnostic and red flag criteria to determine likelihood of MOG-EM diagnosis. Para-/clinical parameters were described and analyzed with chi-square test.

resultsIn total, 37 patients fulfilled MOG-EM diagnostic criteria (female-to-male ratio: 1.6:1, median onset age: 28.0 years [IQR 18.5-40.5], n = 8 with pediatric onset). In 24/37, red flags were present, predominantly MOG-IgG at assay cutoff and/or MRI lesions suggestive of multiple sclerosis (MS). As proposed in the consensus criteria, these patients should rather be described as "possible" MOG-EM. Of these, we classified 13 patients as "unlikely" MOG-EM in the presence of the red flag "borderline MOG-IgG" with negative MOG-IgG retest or coincidence of ≥1 additional red flag. This group mainly consisted of patients diagnosed with MS (n = 11). Frequency of cerebrospinal fluid (CSF-)-specific oligoclonal bands (OCB) is significantly lower in definite vs possible and unlikely MOG-EM (P = .0005).

conclusionEvaluation of diagnostic and red flag criteria, MOG-IgG retesting (incl. change of assay), and CSF-specific OCB are relevant in clinical routine cohorts to differentiate MOG-EM from MS.

Indexed as

AdolescentAdultAutoantibodiesCohort StudiesEncephalomyelitisFemaleHEK293 CellsHumansImmunoglobulin GMagnetic Resonance ImagingMaleMyelin-Oligodendrocyte GlycoproteinRetrospective StudiesYoung AdultAutoantibodiesImmunoglobulin GMyelin-Oligodendrocyte Glycoproteincerebrospinal fluidmultiple sclerosismyelin oligodendrocyte glycoproteinneuromyelitis optica spectrum disorders

Identifiers

PMID33047894
PMCPMC7941167
OpenAlexW3092600921

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.