Evidence map›Paper›PMID 33047737›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2020

[Improved synthesis process of optical-magnetic bimodal probe of Gd-[4, 7-Bis-carboxymethyl-10-(2-fluoresceinthioureaethyl)-1, 4, 7, 10-tetraaza-cyclododec-1-yl]-acetic acid complexes].

H Sheng, L Liang, T L Zhou, Y X Jia, T Wang, L Yuan, H B Han

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

H ShengDepartment of Chemical Biology, Peking University School of Pharmaceutical Sciences, Beijng 100191, China.
L LiangDepartment of Medicinal Chemistry, Peking University School of Pharmaceutical Sciences, Beijng 100191, China.
T L ZhouDepartment of Medicinal Chemistry, Peking University School of Pharmaceutical Sciences, Beijng 100191, China.
Y X JiaDepartment of Medicinal Chemistry, Peking University School of Pharmaceutical Sciences, Beijng 100191, China.
T WangDepartment of Chemical Biology, Peking University School of Pharmaceutical Sciences, Beijng 100191, China.
L YuanDepartment of Chemical Biology, Peking University School of Pharmaceutical Sciences, Beijng 100191, China.
H B HanBeijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China.
Peking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo improve the methods to synthesize and purify of optical-magnetic bimodal molecular probe of Gd-[4, 7-Bis-carboxymethyl-10-(2-fluorescein thioureaethyl)-1, 4, 7, 10-tetraaza-cyclododec-1-yl]-acetic acid complexes.

methodsTarget compound (7), optical-magnetic bimodal molecular molecular probe, was synthesized by the use of 1, 4, 7, 10-tetraazacyclododecane (1) as starting material via substitution reaction, hydrolysis reaction, coupling reaction and complexation reaction with metal.

resultsThe synthetic route of Gd-[4, 7-Bis-carboxymethyl-10-(2-fluoresceinthioureaethyl)-1, 4, 7, 10-tetraaza-cyclododec-1-yl]-acetic acid complexes was improved. The optical-magnetic bimodal molecular probes were synthesized by substitution reaction, hydrolysis reaction, coupling reaction and complex reaction with metal respectively. For the improved route, the total yield could reach 34.6% which was higher than the original route (18.0%). The structures of those compounds were identified by

conclusionThe improved synthetic route improves the controllability of the reaction conditions and makes it easier to purify and separate the compounds. At the same time, the improved synthetic route can increase the total yield significantly. The optical-magnetic bimodal molecular probe can combine the living magnetic resonance imaging with the

Indexed as

Acetic AcidMagnetic Resonance ImagingBrainMagnetic Resonance SpectroscopyMolecular ProbesAcetic AcidMolecular ProbesBimodal imagingBimodal probeChemical synthesisMagnetic resonance imagingOptical imaging

Identifiers

PMID33047737
PMCPMC7653407
OpenAlexW3118292477

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