Evidence map›Paper›PMID 33047713›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2020

[Evaluating the effect of WNT pathway genes considering interactions on the risk of non-syndromic oral clefts among Chinese populations].

M Y Wang, W Y Li, R Zhou, S Y Wang, D J Liu, H C Zheng, J Li, N Li, Z B Zhou, H P Zhu and 2 more

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Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

M Y WangDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
W Y LiDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
R ZhouDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
S Y WangDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
D J LiuDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
H C ZhengDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
J LiDepartment of Pediatric Dentistry, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
N LiDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Z B ZhouDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China.
H P ZhuDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China.
T WuDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
Y H HuDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn this study, we used genome-wide association study (GWAS) data to explore whether WNT pathway genes were associated with non-syndromic oral clefts (NSOC) considering gene-gene interaction and gene-environment interaction.

methodsWe conducted the analysis using 806 non-syndromic cleft lip with or without cleft palate (NSCL/P) case-parent trios and 202 non-syndromic cleft palate (NSCP) case-parent trios among Chinese populations selected from an international consortium established for a GWAS of non-syndromic oral clefts. Genotype data and maternal environmental exposures were collected through DNA samples and questionnaires. Conditional Logistic regression models were adopted to explore gene-gene interaction and gene-environment in teraction using trio package in R software. The threshold of significance level was set as 3.47×10

resultsA total of 144 single nucleotide polymorphisms (SNPs) in seven genes passed the quality control process in NSCL/P trios and NSCP trios, respectively. Totally six pairs of SNPs interactions showed statistically significant SNP-SNP interaction (

conclusionThough this study failed to detect significant association based on gene-environment interactions of seven WNT pathway genes and the risk of NSOC, WNT pathway genes may influence the risk of NSOC through potential gene-gene interaction.

Indexed as

Cleft LipCleft PalateAsian PeopleGenome-Wide Association StudyHumansWnt Signaling PathwayGenome-wide association studiesNon-syndromic oral cleftsWNT signaling pathway

Identifiers

PMID33047713
PMCPMC7653429

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