ArticleeLife2020
Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Avoiding cancer through collective behaviour.Nature reviews. Cancer · 2026Article
- Correlation between ocular tumor distribution and age based on analysis of pathological specimens.American journal of translational research · 2026Article
- Crosstalk in Skin: Loss of Desmoglein 1 in Keratinocytes Inhibits BRAFThe Journal of investigative dermatology · 2025Article
- Uncovering minimal pathways in melanoma initiation.Nature communications · 2025Article
- Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFOncogene · 2025Article
- Transdermal delivery of ultradeformable cationic liposomes complexed with miR211-5p (UCL-211) stabilizes BRAFV600E+ melanocytic nevi.Journal of controlled release : official journal of the Controlled Release Society · 2025Article
- Prognostic Value of Nevus-Associated Melanoma in Patients with Melanoma.Annals of surgical oncology · 2025Article
- The Pivotal Role of One-Carbon Metabolism in Neoplastic Progression During the Aging Process.Biomolecules · 2024Review
- Transdermal Delivery of Ultradeformable Cationic Liposomes Complexed with miR211-5p (UCL-211) Stabilizes BRAFV600E+ Melanocytic Nevi.bioRxiv : the preprint server for biology · 2024Article
- Nevi and Melanoma.Hematology/oncology clinics of North America · 2024Review
- MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling.Nature communications · 2024Article
- Assessment of RAS-RAF-MAPK Pathway Mutation Status in Healthy Skin, Benign Nevi, and Cutaneous Melanomas: Pilot Study Using Droplet Digital PCR.International journal of molecular sciences · 2024Article
- Article
- Mettl3-catalyzed mScience advances · 2023Article
- The journey from melanocytes to melanoma.Nature reviews. Cancer · 2023Review
- Localized immune surveillance of primary melanoma in the skin deciphered through executable modeling.Science advances · 2023Article
- Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction.Cell reports · 2023Article
- Inactivation of the Hippo tumor suppressor pathway promotes melanoma.Nature communications · 2022Article
- Paradoxical Behavior of Oncogenes Undermines the Somatic Mutation Theory.Biomolecules · 2022Article
- Cancer progression as a learning process.iScience · 2022Review
Corrections and comments
- Commented on by
Authors and funding
11 authors at 1 institution in 1 country.
Rolando Ruiz-VegaCenter for Complex Biological Systems, University of California, Irvine, Irvine, United States.
Chi-Fen ChenDepartment of Dermatology, University of California, Irvine, Irvine, United States.
Emaad RazzakCenter for Complex Biological Systems, University of California, Irvine, Irvine, United States.
Priya VasudevaDepartment of Dermatology, University of California, Irvine, Irvine, United States.
Tatiana B KrasievaBeckman Laser Institute, University of California, Irvine, Irvine, United States.
Jessica ShiuDepartment of Dermatology, University of California, Irvine, Irvine, United States.
Michael G CaldwellCenter for Complex Biological Systems, University of California, Irvine, Irvine, United States.
Huaming YanDepartment of Mathematics, University of California, Irvine, Irvine, United States.
John LowengrubCenter for Complex Biological Systems, University of California, Irvine, Irvine, United States.
Anand K GanesanCenter for Complex Biological Systems, University of California, Irvine, Irvine, United States.ORCID 0000-0003-4944-9274
Arthur D LanderCenter for Complex Biological Systems, University of California, Irvine, Irvine, United States.ORCID 0000-0002-4380-5525
University of California, Irvine · US
Funding
Shared Resource Core: Single Cell AnalysisU54CA217378 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI VAN ETTEN, RICHARD A. · 2018 to 2022
$9.7MCARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6MUCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1MMultiscale Models of Wound Cell Plasticity for RegenerationU01AR073159 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAI, XING, NIE, QING · 2018 to 2022
$3.5MMentor Training to enhance mentorship in an interdisciplinary training programT32GM136624 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Arthur D Lander, Qing Nie · 2020 to 2026
$3.1MMathematical, Computational and Systems BiologyT32EB009418 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI LANDER, ARTHUR D, NIE, QING · 2009 to 2019
$2.4MNCI NIH HHS T32 CA009054NCI NIH HHS U54 CA217378NIAMS NIH HHS P30 AR075047NIAMS NIH HHS U01 AR073159NIBIB NIH HHS T32 EB009418NIGMS NIH HHS T32 GM136624
Abstract
Mutational activation of the
Indexed as
Cell CommunicationAnimalsMelanocytesMiceNevusNevus, PigmentedProto-Oncogene MasProto-Oncogene Proteins B-rafBraf protein, mouseMAS1 protein, humanProto-Oncogene MasProto-Oncogene Proteins B-rafbraf mutationcancer biologycomputational biologymelanocytesmousenevusnevus mouse modeloncogene induced senescenceskinsystems biology
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.