Evidence map›Paper›PMID 33047420›Full record

ArticleHead & neck2021

Impact of treatment delay on survival of oral/oropharyngeal cancers: Results of a nationwide screening program.

William Wang-Yu Su, Yi-Huah Lee, Amy Ming-Fang Yen, Sam Li-Sheng Chen, Chen-Yang Hsu, Sherry Yueh-Hsia Chiu, Jean Ching-Yuan Fann, Yi-Chia Lee, Han-Mo Chiu, Shu-Chun Hsiao and 2 more

Abstract read
In one paragraph

Article in Head & neck, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

William Wang-Yu SuDivision of Otorhinolaryngology-Head & Neck Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.ORCID 0000-0003-1640-2920
Yi-Huah LeeInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Amy Ming-Fang YenSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Sam Li-Sheng ChenSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0001-9750-3015
Chen-Yang HsuInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Sherry Yueh-Hsia ChiuDepartment of Health Care Management and Healthy Aging Research Center, Chang Gung University, Tao-Yuan, Taiwan.
Jean Ching-Yuan FannDepartment of Health Industry Management, College of Healthcare Management, Kainan University, Tao-Yuan, Taiwan.
Yi-Chia LeeDepartment of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0002-8160-1216
Han-Mo ChiuDepartment of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Shu-Chun HsiaoHealth Promotion Administration, Ministry of Health and Welfare, Cancer Prevention and Control Division, Taiwan.
Tsui-Hsia HsuHealth Promotion Administration, Ministry of Health and Welfare, Cancer Prevention and Control Division, Taiwan.
Hsiu-Hsi ChenInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC).

methodsWe followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012.

resultsThe hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. The corresponding figures were 1.12 (1.01-1.24) and 1.00 (0.91-1.11) for treatment delay between 3 and 6 weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P < .05). However, treatment at medical center had a lower mortality (0.83, 0.75-0.91) than local/regional hospital.

conclusionsTreatment delay longer than 6 weeks for OSCCs detected via a population-based screening program had unfavorable survival.

Indexed as

Mouth NeoplasmsOropharyngeal NeoplasmsArecaEarly Detection of CancerHumansRisk FactorsTime-to-Treatmentbetel quid chewingcigarette smokingoral/oropharyngeal cancersurvivaltreatment delay

Identifiers

PMID33047420
PMCPMC7820997

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.