Evidence map›Paper›PMID 33047248›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

IntraOmmaya compartmental radioimmunotherapy using

Rahul S Yerrabelli, Ping He, Edward K Fung, Kim Kramer, Pat B Zanzonico, John L Humm, Hongfen Guo, Neeta Pandit-Taskar, Steven M Larson, Nai-Kong V Cheung

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00089245 (Phase I Study Of Intrathecal Radioimmunotherapy Using I-8H9 For Central Nervous System/Leptomeningeal Neoplasms), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00089245 phase1terminatednot on this map

Phase I Study Of Intrathecal Radioimmunotherapy Using I-8H9 For Central Nervous System/Leptomeningeal Neoplasms

TypeinterventionalSponsorY-mAbs TherapeuticsRan2004 to 2022Enrolled177ConditionsBrain and Central Nervous System Tumors, Neuroblastoma, SarcomaArmsIodine I 131 MOAB 8H9
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Phase 1 study of intraventricularJournal of hematology & oncology · 2022
    Article
  8. Review
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rahul S YerrabelliDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.ORCID https://orcid.org/0000-0002-7670-9601
Ping HeRenaissance School of Medicine, Stony Brook University, 101 Nicolls Road, Stony Brook, NY, 11794, USA.
Edward K FungDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Kim KramerDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Pat B ZanzonicoDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
John L HummDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Hongfen GuoDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Neeta Pandit-TaskarDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Steven M LarsonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Nai-Kong V CheungDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. cheungn@mskcc.org.
Memorial Sloan Kettering Cancer Center · USStony Brook School · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeRadioimmunotherapy (RIT) delivered through the cerebrospinal fluid (CSF) has been shown to be a safe and promising treatment for leptomeningeal metastases. Pharmacokinetic models for intraOmmaya antiGD2 monoclonal antibody

methodsSerial CSF samples were collected and radioassayed from 61 patients undergoing a total of 177 intraOmmaya administrations of

resultsThe model fit CSF radioactivity data well (mean R = 96.4%). The median immunoreactivity of

conclusionThe 2-compartmental pharmacokinetic model when applied to intraOmmaya CLINICAL

trial registrationClinicalTrials.gov , NCT00089245.

Indexed as

Iodine RadioisotopesRadioimmunotherapyAntibodies, Monoclonal, Murine-DerivedHumansTherapeutic IndexAntibodies, Monoclonal, Murine-DerivedIodine-131Iodine Radioisotopes131I-omburtamabCerebrospinal fluidNeuroblastomaPharmacokineticsRadioimmunotherapy

Identifiers

PMID33047248
PMCPMC8279045
OpenAlexW3092545853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.