Evidence map›Paper›PMID 33047204›Full record

ArticleClinical oral investigations2021

The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers.

Tabata P Sato, Bruno V M Rodrigues, Daphne C R Mello, Eliseu A Münchow, Juliana S Ribeiro, João Paulo B Machado, Luana M R Vasconcellos, Anderson O Lobo, Marco C Bottino, Alexandre L S Borges

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Article in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tabata P SatoDepartment of Dental Materials and Prosthodontics, Institute of Science and Technology (IST), São Paulo State University (UNESP), Av Engenheiro Francisco José Longo, 777, Jardim São Dimas, São José dos Campos, SP, 12245-200, Brazil.
Bruno V M RodriguesLaboratory of Biomedical Nanotechnology, Universidade Brasil, São Paulo, SP, 08230-030, Brazil.
Daphne C R MelloDepartment of Oral Pathology and Microbiology, IST, UNESP, São José dos Campos, SP, 12245-200, Brazil.
Eliseu A MünchowDepartment of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, 90035-003, Brazil.
Juliana S RibeiroDepartment of Cariology, Restorative Sciences, and Endodontics, University of Michigan School of Dentistry, 1011 N. University (Room 5223), Ann Arbor, MI, 48109, USA.
João Paulo B MachadoAssociated Laboratory of Materials and Sensor (LAS), National Institute of Space Research (INPE), São José dos Campos, SP, 12201-970, Brazil.
Luana M R VasconcellosDepartment of Oral Pathology and Microbiology, IST, UNESP, São José dos Campos, SP, 12245-200, Brazil.
Anderson O LoboLaboratory of Biomedical Nanotechnology, Universidade Brasil, São Paulo, SP, 08230-030, Brazil.
Marco C BottinoDepartment of Cariology, Restorative Sciences, and Endodontics, University of Michigan School of Dentistry, 1011 N. University (Room 5223), Ann Arbor, MI, 48109, USA. mbottino@umich.edu.ORCID http://orcid.org/0000-0001-8740-2464
Alexandre L S BorgesDepartment of Dental Materials and Prosthodontics, Institute of Science and Technology (IST), São Paulo State University (UNESP), Av Engenheiro Francisco José Longo, 777, Jardim São Dimas, São José dos Campos, SP, 12245-200, Brazil. alexandre.borges@unesp.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 310973/2014-7 and 310659/2014-0FAPESP 2011/17877-7 and 2011/20345-7
6 · The paper itself

Abstract

objectivesThis study aimed to evaluate the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers. MATERIALS AND

methodsnHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers). Neat chitosan fibers (nHAp-free, Ch fibers) were used as the control. The electrospun fiber mats were characterized using morphological, topographical, chemical, thermal, and a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses. Data were analyzed using ANOVA and Tukey's test (α = 0.05).

resultsChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers. Despite showing similar cell viability and ALP activity to Ch fibers, the ChHa fibers demonstrated greater antibacterial potential against most tested bacteria (except for P. intermedia), and higher antibiofilm activity against P. gingivalis biofilm.

conclusionsThe incorporation of nHAp particles did not jeopardize the overall morphology, topography, physical, and biological characteristics of the chitosan nanofibers. CLINICAL RELEVANCE: The combination of nHAp particles with chitosan can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry.

Indexed as

ChitosanNanofibersDurapatitePolymersChitosanDurapatitePolymersAntimicrobialChitosanElectrospinningRegenerationRegenerative dentistryScaffolds

Identifiers

PMID33047204

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.