Evidence map›Paper›PMID 33047067›Full record

ArticleRoyal Society open science2020

Nanofibrous cosmetic face mask for transdermal delivery of nano gold: synthesis, characterization, release and zebra fish employed toxicity studies.

D C Manatunga, V U Godakanda, H M L P B Herath, Rohini M de Silva, Chen-Yu Yeh, Jiann-Yeu Chen, A A Akshitha de Silva, S Rajapaksha, Renuka Nilmini, K M Nalin de Silva

Open access · goldAbstract read
In one paragraph

Article in Royal Society open science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Nanomaterials in Skin Regeneration and Rejuvenation.International journal of molecular sciences · 2021
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

D C ManatungaCentre for Advanced Materials and Devices, Department of Chemistry, University of Colombo, Colombo 00300, Sri Lanka.ORCID 0000-0003-1489-5557
V U GodakandaCentre for Advanced Materials and Devices, Department of Chemistry, University of Colombo, Colombo 00300, Sri Lanka.ORCID 0000-0002-2489-7903
H M L P B HerathCentre for Advanced Materials and Devices, Department of Chemistry, University of Colombo, Colombo 00300, Sri Lanka.
Rohini M de SilvaCentre for Advanced Materials and Devices, Department of Chemistry, University of Colombo, Colombo 00300, Sri Lanka.ORCID 0000-0003-0955-6366
Chen-Yu YehDepartment of Chemistry, National Chung Hsing University, Taichung 402, Taiwan.
Jiann-Yeu ChenResearch Centre for Sustainable Energy and Nanotechnology (RCSEN), National Chung Hsing University, Taichung 402, Taiwan.
A A Akshitha de SilvaDepartment of Chemistry, National Chung Hsing University, Taichung 402, Taiwan.
S RajapakshaDepartment of Engineering Technology, Faculty of Technology, University of Sri Jayawardenapura, Sri Lanka.
Renuka NilminiDepartment of Engineering Technology, Faculty of Technology, University of Sri Jayawardenapura, Sri Lanka.
K M Nalin de SilvaCentre for Advanced Materials and Devices, Department of Chemistry, University of Colombo, Colombo 00300, Sri Lanka.ORCID 0000-0003-3219-3233
University of Colombo · LKNational Chung Hsing University · TWUniversity of Sri Jayewardenepura · LK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study involves the generation of gold nanoparticles (Au NPs) via a novel natural/non-toxic methodology using tea and orange-peel extracts. These were then embedded into a novel blend composed of a polyethylene oxide and gelatin (PEO-Gel) fibre mat. The scanning electron microscopy results indicated that the addition of both collagen (COL) and ascorbic acid (AA) into the PEO-Gel system (PEO-Gel-AA-COL system) enhances the Au NP incorporation into nanofibres leading to a diameter of 164.60 ± 20.95 and 192.43 ± 39.14 nm in contrast to the spraying observed with the Au PEO-Gel system alone. Releasing studies conducted over 30 min indicated that the PEO-Gel-AA-COL-orange peel Au (OpAu) system accounts for a higher content of Au release than the green tea Au (GtAu) NP system where a maximum release could be attained within 10-30 min depending on the amount of Au NPs that have been incorporated. Moreover, the transdermal diffusion studies conducted using Strat membrane indicated that Au NPs from both formulations (PEO-Gel-AA-COL-GtAu nanofibre, PEO-Gel-AA-COL-OpAu nanofibre) have diffused through the stratum corneum and trapped in the dermis and epidermis indicating its transdermal deliverability. Additionally, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay revealed that nanofibres have similar radical scavenging activity like AA standard. Toxicity evaluation on a zebra fish embryo model confirmed that both GtAu NPs and OpAu NPs do not induce any teratogenic activity and are safe to be used in the range of 1.0-167 µg ml

Indexed as

gold nanoparticlesgreen teananofibresorange peelskin masktransdermal delivery

Identifiers

PMID33047067
PMCPMC7540761
OpenAlexW3091484771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.