Evidence map›Paper›PMID 33046890›Full record

ReviewNature neuroscience2020

Neural mechanisms of aggression across species.

Julieta E Lischinsky, Dayu Lin

Abstract readReview
In one paragraph

Review in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Neural basis of social hierarchy across species.Nature reviews. Neuroscience · 2026
    Review
  9. Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Sexual Dimorphism in c-Fos Networks Governing Aggression.bioRxiv : the preprint server for biology · 2026
    Article
  14. Dopamine modulation of aggression.Psychopharmacology · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Sex differences in the neural circuitry of aggression.bioRxiv : the preprint server for biology · 2025
    Article

70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Julieta E LischinskyNeuroscience Institute, New York University School of Medicine, New York, NY, USA.
Dayu LinNeuroscience Institute, New York University School of Medicine, New York, NY, USA. Dayu.Lin@nyulangone.org.ORCID http://orcid.org/0000-0003-2006-0791

Funding

U19 Supplement 2023-FroemkeU19NS107616 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RICHARD W TSIEN · 2018 to 2026
$36.4M
Research Supplement to Promote Diversity in Health-Related ResearchR01MH101377 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dayu Lin · 2013 to 2026
$8.6M
Understand the neural mechanism underlying aggressive motivationR21MH105774 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIN, DAYU · 2016 to 2017
$466k
NIMH NIH HHS R01 MH101377NIMH NIH HHS R21 MH105774NINDS NIH HHS U19 NS107616
6 · The paper itself

Abstract

Aggression is a social behavior essential for securing resources and defending oneself and family. Thanks to its indispensable function in competition and thus survival, aggression exists widely across animal species, including humans. Classical works from Tinbergen and Lorenz concluded that instinctive behaviors including aggression are mediated by hardwired brain circuitries that specialize in processing certain sensory inputs to trigger stereotyped motor outputs. They further suggest that instinctive behaviors are influenced by an animal's internal state and past experiences. Following this conceptual framework, here we review our current understanding regarding the neural substrates underlying aggression generation, highlighting an evolutionarily conserved 'core aggression circuit' composed of four subcortical regions. We further discuss the neural mechanisms that support changes in aggression based on the animal's internal state. We aim to provide an overview of features of aggression and the relevant neural substrates across species, highlighting findings in rodents, primates and songbirds.

Indexed as

AggressionAnimalsBehavior, AnimalBrainHumansNeural PathwaysNeuronsSpecies Specificity

Identifiers

PMID33046890
PMCPMC13152643

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.