ArticleNature immunology2020
Two subsets of stem-like CD8
Open access · greenAbstract read
In one paragraph
Article in Nature immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed, 1 pooled it
14.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
201 citing papers in PubMed, 1 synthesis or guideline pooled it, 312 citations in OpenAlex.
- Prognostic Impact of Memory CD8(+) T Cells on Immunotherapy in Human Cancers: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Distinct CD8Cancer cell · 2025Trial
- Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy.Cell reports. Medicine · 2025Trial
- A Phase II Open-Label, Randomized Clinical Trial of Atezolizumab with or without Human Recombinant IL-7 (CYT107) in Advanced Urothelial Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Trial
- Phase II Trial of Pembrolizumab after High-Dose Cytarabine in Relapsed/Refractory Acute Myeloid Leukemia.Blood cancer discovery · 2021Trial
- Epigenetic plus cytokine therapy induces stem-like CD8Journal for immunotherapy of cancer · 2026Article
- Programmable CAR-engaging particles rewire human CAR T-cell signaling for sustainable ex vivo expansion.Nature communications · 2026Article
- T Cell Thoughts.Immunological reviews · 2026Review
- Fusion-driven oncogenic programs shape the immune landscape in translocation renal cell carcinoma.Nature communications · 2026Article
- Molecular heterogeneity and clonal origin of CCR8Nature communications · 2026Article
- Clonal sharing and plasticity of follicular CD4 + T cells across lymph nodes and tumors in non-small cell lung cancer.Nature communications · 2026Article
- CD8Cell reports. Medicine · 2026Review
- Airway immune signatures of protection and disease progression in recent human tuberculosis household contacts.Nature immunology · 2026Article
- Renaissance of antiviral CD8Nature reviews. Immunology · 2026Review
- Human inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity.medRxiv : the preprint server for health sciences · 2026Article
- BATF3 regulates differentiation of CD8Life science alliance · 2026Article
- New insights into progenitor exhausted T cell populations.Nature reviews. Immunology · 2026Article
- Article
- Nur77 Is Associated With Polyfunctional Properties in Virus-Specific Human CD8European journal of immunology · 2026Article
- CD28-driven ex vivo generation of stem-like memory CD8Proceedings of the National Academy of Sciences of the United States of America · 2026Article
141 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
32 authors at 8 institutions in 6 countries.
Giovanni Galletti *Laboratory of Translational Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.ORCID http://orcid.org/0000-0001-6613-2354
Gabriele De Simone *Laboratory of Translational Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Emilia M C Mazza *Laboratory of Translational Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Simone PuccioLaboratory of Translational Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Claudia MezzanotteInnovative Immunotherapies Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Timothy M BiVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Alexey N DavydovCentral European Institute of Technology, Brno, Czech Republic.
Maria MetsgerCentral European Institute of Technology, Brno, Czech Republic.ORCID http://orcid.org/0000-0001-9722-0533
Eloise ScamardellaLaboratory of Translational Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Giorgia AlvisiLaboratory of Translational Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Federica De PaoliLaboratory of Translational Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Veronica ZanonLaboratory of Translational Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Alice ScarpaLaboratory of Translational Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Barbara CamisaInnovative Immunotherapies Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Federico S ColomboHumanitas Flow Cytometry Core, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.ORCID http://orcid.org/0000-0003-4480-3481
Achille AnselmoHumanitas Flow Cytometry Core, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Clelia PeanoInstitute of Genetic and Biomedical Research, UoS Milan, National Research Council, Rozzano, Milan, Italy.ORCID http://orcid.org/0000-0001-7055-3629
Sara PollettiDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Domenico MavilioUnit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.ORCID http://orcid.org/0000-0001-6147-0952
Luca GattinoniCenter for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2239-3282
Shannon K BoiSt. Jude Children's Research Hospital, Memphis, TN, USA.
Benjamin A YoungbloodSt. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-1261-9957
Rhiannon E JonesDivision of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK.
Duncan M BairdDivision of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK.
Emma GostickDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Sian Llewellyn-LaceyDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Kristin LadellDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.ORCID http://orcid.org/0000-0002-9856-2938
David A PriceDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.ORCID http://orcid.org/0000-0001-9416-2737
Dmitriy M ChudakovShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.ORCID http://orcid.org/0000-0003-0430-790X
Evan W NewellVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2889-243X
Monica CasucciInnovative Immunotherapies Unit, Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Enrico LugliLaboratory of Translational Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy. enrico.lugli@humanitasresearch.it.ORCID http://orcid.org/0000-0002-1964-7678
Humanitas University · ITCardiff University · GBVita-Salute San Raffaele University · ITCentral European Institute of Technology · CZFred Hutch Cancer Center · USSt. Jude Children's Research Hospital · USSkolkovo Institute of Science and Technology · RUUniversity Hospital Regensburg · DE
Funding
Cancer Research UK 18246Cancer Research UK 29202Cancer Research UK C17199/A18246/A29202European Research Council 640511Wellcome Trust 100326Wellcome Trust 100326/Z/12/Z
Abstract
T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors has remained unclear, precluding a full understanding of the differentiation trajectories that underpin the heterogeneity of antigen-experienced T cells. We used a systematic approach guided by single-cell RNA-sequencing data to map the organizational structure of the human CD8
Indexed as
Immunologic MemoryAnimalsBiomarkersCD8-Positive T-LymphocytesCell DifferentiationComputational BiologyGene Expression ProfilingHigh-Throughput Nucleotide SequencingHumansImmunophenotypingLymphoid Progenitor CellsMiceTelomere HomeostasisT-Lymphocyte SubsetsBiomarkers
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.