Evidence map›Paper›PMID 33046652›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Filtering input fluctuations in intensity and in time underlies stochastic transcriptional pulses without feedback.

Alberto Stefano Sassi, Mayra Garcia-Alcala, Mark J Kim, Philippe Cluzel, Yuhai Tu

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Non-Genetic Diversity in Chemosensing and Chemotactic Behavior.International journal of molecular sciences · 2021
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alberto Stefano SassiDepartment of AI Science, IBM T. J. Watson Research Center, Yorktown Heights, NY 10598.ORCID 0000-0002-1269-4746
Mayra Garcia-AlcalaDepartment of Molecular and Cellular Biology, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.ORCID 0000-0001-7425-1767
Mark J KimDepartment of Molecular and Cellular Biology, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.ORCID 0000-0002-2753-8770
Philippe CluzelDepartment of Molecular and Cellular Biology, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.ORCID 0000-0001-8545-1879
Yuhai TuDepartment of AI Science, IBM T. J. Watson Research Center, Yorktown Heights, NY 10598; yuhai@us.ibm.com.ORCID 0000-0002-4589-981X

Funding

Molecular Mechanisms and Biochemical Circuits for Adaptation in Biological SystemsR35GM131734 · NIGMS · IBM THOMAS J. WATSON RESEARCH CENTER · PI TU, YUHAI · 2019 to 2024
$1.8M
Noise, memory, and adaptation in the flagellum system in E.coli.R01GM134275 · NIGMS · HARVARD UNIVERSITY · PI CLUZEL, PHILIPPE · 2019 to 2020
$642k
NIGMS NIH HHS R01 GM134275NIGMS NIH HHS R35 GM131734
6 · The paper itself

Abstract

Stochastic pulsatile dynamics have been observed in an increasing number of biological circuits with known mechanism involving feedback control and bistability. Surprisingly, recent single-cell experiments in

Indexed as

Gene Expression Regulation, BacterialModels, BiologicalStochastic ProcessesCarrier ProteinsEscherichia coliEscherichia coli ProteinsTime FactorsTrans-ActivatorsCarrier ProteinsEscherichia coli ProteinsflhD protein, E coliTrans-ActivatorsYdiV protein, E colifilteringgene regulationstochastic modelingtranscriptional pulsesultrasensitivity

Identifiers

PMID33046652
PMCPMC7604450

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.