Evidence map›Paper›PMID 33046644›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection.

Caitlin E Edwards, Boyd L Yount, Rachel L Graham, Sarah R Leist, Yixuan J Hou, Kenneth H Dinnon, Amy C Sims, Jesica Swanstrom, Kendra Gully, Trevor D Scobey and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed
2.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 164 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cell entry mechanisms of porcine enteric coronaviruses.The Journal of biological chemistry · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Suidae Coronaviruses: Epidemiology, Transmission, and Molecular Diagnosis.Animals : an open access journal from MDPI · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Effects ofiMetaOmics · 2025
    Article
  20. Article

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Caitlin E EdwardsDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0003-4228-2192
Boyd L YountDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Rachel L GrahamDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0002-3143-6515
Sarah R LeistDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0002-4989-5381
Yixuan J HouDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0002-8323-7243
Kenneth H DinnonDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Amy C SimsChemical and Biological Signatures Division, Pacific Northwest National Laboratory, Richland, WA 99354.
Jesica SwanstromDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Kendra GullyDepartment of Comparative Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0001-5742-2341
Trevor D ScobeyDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0001-8313-5434
Michelle R CooleyDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Caroline G CurrieDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Scott H RandellMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Ralph S BaricDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; rbaric@email.unc.edu.
University of North Carolina at Chapel Hill · USPacific Northwest National Laboratory · US

Funding

Project 4 - Influenza - UABU19AI142759 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PATHAK, ASHISH KUMAR · 2019 to 2023
$37.5M
Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Martina Gentzsch · 2004 to 2026
$26.5M
Broad-spectrum antiviral GS-5734 to treat MERS-CoV and related emerging CoVR01AI132178 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S, SHEAHAN, TIMOTHY PATRICK · 2017 to 2021
$7.0M
Understanding Risk of Zoonotic Virus Emergence in EID Hotspots of Southeast AsiaU01AI151797 · NIAID · ECOHEALTH ALLIANCE, INC. · PI DASZAK, PETER · 2020 to 2023
$6.0M
Receptor recognition mechanisms of coronavirusesR01AI089728 · NIAID · UNIVERSITY OF MINNESOTA · PI Fang Li, Timothy Patrick Sheahan · 2010 to 2026
$4.7M
Understanding the Risk of Bat Coronavirus EmergenceR01AI110964 · NIAID · ECOHEALTH ALLIANCE, INC. · PI DASZAK, PETER · 2014 to 2023
$4.3M
NIAID NIH HHS R01 AI089728NIAID NIH HHS R01 AI110964NIAID NIH HHS R01 AI132178NIAID NIH HHS U01 AI151797NIAID NIH HHS U19 AI142759NIDDK NIH HHS P30 DK065988NIH HHS AI089728NIH HHS AI132178NIH HHS AI142759NIH HHS AI151797NIH HHS DK065988
6 · The paper itself

Abstract

Zoonotic coronaviruses represent an ongoing threat, yet the myriads of circulating animal viruses complicate the identification of higher-risk isolates that threaten human health. Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a newly discovered, highly pathogenic virus that likely evolved from closely related HKU2 bat coronaviruses, circulating in

Indexed as

Virus ReplicationAdenosine MonophosphateAlanineAlphacoronavirusAnimalsCells, CulturedChlorocebus aethiopsCoronavirus InfectionsDisease SusceptibilityGene ExpressionHost SpecificityHumansLuminescent ProteinsMiceVero CellsAdenosine MonophosphateAlanineLuminescent Proteinsremdesivircoronavirusemerging infectious diseaseOne HealthSADS

Identifiers

PMID33046644
PMCPMC7604506
OpenAlexW3092011752

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.