ArticleProceedings of the National Academy of Sciences of the United States of America2020
Nucleus accumbens cytoarchitecture predicts weight gain in children.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06387719 (Precursors of Binge Eating Disorder in a Clinical Sample of Adolescents With Obesity), which is not on this map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Precursors of Binge Eating Disorder in a Clinical Sample of Adolescents With Obesity: Early MRI Markers of Brain Reward and Inhibition Processing Dysfunction
Who cites it
45 citing papers in PubMed, 77 citations in OpenAlex.
- The impact of 4-week high-intensity interval training on mental health and sleep quality in female college students with normal weight obesity: a randomized controlled trial.Journal of translational medicine · 2025Trial
- Feasibility of ConcurrentNMR in biomedicine · 2026Article
- Weight gain and brain development in the ABCD study cohort: A decade of insight and the road ahead.Developmental cognitive neuroscience · 2026Review
- Restriction spectrum imaging reveals brain microstructural correlates of obesity risk in early childhood.Scientific reports · 2026Article
- Cardiometabolic Risk and Structural Brain Development in a Large Community-Based US Cohort.Human brain mapping · 2026Article
- The unique effects of chronic exposure to ambient fine particulate matter and indoor radon on subcortical brain morphology in youth.Neurotoxicology · 2026Article
- Nonlinear associations between body mass index and brain microstructure across adolescence in the ABCD Study.bioRxiv : the preprint server for biology · 2026Article
- Voluntary Long-Term Exercise by Female Mice Modulates Anxiety-Like Behavior and Motor Function but Minimally Impacts Acute Oxidative Injury in the Central Nervous System.The European journal of neuroscience · 2025Article
- Brain Microstructure and Obesity Risk in Early Childhood: Insights from Restriction Spectrum Imaging.bioRxiv : the preprint server for biology · 2025Article
- Dissecting the Causal Association Between Bulimia Nervosa and Structural Brain Abnormalities: A Two-Sample Bidirectional Mendelian Randomization Study.Brain and behavior · 2025Article
- Striatal astrocytes modulate behavioral flexibility and whole-body metabolism in mice.Nature communications · 2025Article
- Distinct Patterns of Weight Gain, Age, and Subcortical Microstructure in Early Adolescence.JAMA network open · 2025Observational
- Smaller Subcortical Volume in Reward Processing Regions Precedes Weight Gain in Youth With High Financial Adversity: Findings From the Adolescent Brain Cognitive Development Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025Article
- Genomic structural equation modeling of impulsivity and risk-taking traits reveals three latent factors distinctly associated with brain structure and development.bioRxiv : the preprint server for biology · 2025Article
- Lower Cortisol and Dehydroepiandrosterone Sulfate and Higher Food Addiction in Childhood Obesity: Associations With Stress and Dietary Parameters.Journal of the Endocrine Society · 2025Article
- Ultra-processed food consumption affects structural integrity of feeding-related brain regions independent of and via adiposity.npj metabolic health and disease · 2025Article
- Sex and mental health are related to subcortical brain microstructure.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Air pollution from biomass burning disrupts early adolescent cortical microarchitecture development.Environment international · 2024Article
- FTO variation and early frontostriatal brain development in children.Obesity (Silver Spring, Md.) · 2024Article
- Longitudinal relationships between lifestyle risk factors and neurodevelopment in early adolescence.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The prevalence of obesity in children and adolescents worldwide has quadrupled since 1975 and is a key predictor of obesity later in life. Previous work has consistently observed relationships between macroscale measures of reward-related brain regions (e.g., the nucleus accumbens [NAcc]) and unhealthy eating behaviors and outcomes; however, the mechanisms underlying these associations remain unclear. Recent work has highlighted a potential role of neuroinflammation in the NAcc in animal models of diet-induced obesity. Here, we leverage a diffusion MRI technique, restriction spectrum imaging, to probe the microstructure (cellular density) of subcortical brain regions. More specifically, we test the hypothesis that the cell density of reward-related regions is associated with obesity-related metrics and early weight gain. In a large cohort of nine- and ten-year-olds enrolled in the Adolescent Brain Cognitive Development (ABCD) study, we demonstrate that cellular density in the NAcc is related to individual differences in waist circumference at baseline and is predictive of increases in waist circumference after 1 y. These findings suggest a neurobiological mechanism for pediatric obesity consistent with rodent work showing that high saturated fat diets increase gliosis and neuroinflammation in reward-related brain regions, which in turn lead to further unhealthy eating and obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.