Evidence map›Paper›PMID 33046550›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Inactivation of the GATA Cofactor ZFPM1 Results in Abnormal Development of Dorsal Raphe Serotonergic Neuron Subtypes and Increased Anxiety-Like Behavior.

Laura Tikker, Plinio Casarotto, Parul Singh, Caroline Biojone, T Petteri Piepponen, Nuri Estartús, Anna Seelbach, Ravindran Sridharan, Liina Laukkanen, Eero Castrén and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. A discrete serotonergic circuit involved in the generation of tinnitus behavior.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Decoding serotonin: the molecular symphony behind depression.Frontiers in cellular neuroscience · 2025
    Review
  6. Article
  7. A Unique "Reversed" Migration of Neurons in the Developing Claustrum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  8. Article
  9. ZFPM1 Necessary for Development of Serotonergic Projections Related to Anxiety and Contextual Fear Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Laura TikkerMolecular and Integrative Biosciences Research Programme, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0003-1324-4234
Plinio CasarottoNeuroscience Center - HiLife, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0002-1090-4631
Parul SinghMolecular and Integrative Biosciences Research Programme, University of Helsinki, FIN-00014 Helsinki, Finland.
Caroline BiojoneNeuroscience Center - HiLife, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0002-9674-4930
T Petteri PiepponenDivision of Pharmacology and Pharmacotherapy, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0002-2318-1612
Nuri EstartúsMolecular and Integrative Biosciences Research Programme, University of Helsinki, FIN-00014 Helsinki, Finland.
Anna SeelbachMolecular and Integrative Biosciences Research Programme, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0002-7908-7369
Ravindran SridharanMolecular and Integrative Biosciences Research Programme, University of Helsinki, FIN-00014 Helsinki, Finland.
Liina LaukkanenNeuroscience Center - HiLife, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0003-4245-2809
Eero CastrénNeuroscience Center - HiLife, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0002-1402-2791
Juha PartanenMolecular and Integrative Biosciences Research Programme, University of Helsinki, FIN-00014 Helsinki, Finland juha.m.partanen@helsinki.fi.ORCID 0000-0001-8850-4825
University of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serotonergic neurons in the dorsal raphe (DR) nucleus are associated with several psychiatric disorders including depression and anxiety disorders, which often have a neurodevelopmental component. During embryonic development, GATA transcription factors GATA2 and GATA3 operate as serotonergic neuron fate selectors and regulate the differentiation of serotonergic neuron subtypes of DR. Here, we analyzed the requirement of GATA cofactor ZFPM1 in the development of serotonergic neurons using

Indexed as

Serotonergic NeuronsAnimalsAnxietyBehavior, AnimalBrain ChemistryDorsal Raphe NucleusFearFemaleFluoxetineGATA Transcription FactorsMaleMemoryMiceMice, KnockoutMutationPregnancyFluoxetineGATA Transcription FactorsSelective Serotonin Reuptake InhibitorsSerotoninTranscription FactorsZfpm1 protein, mouseanxietydifferentiationdorsal rapheembryoserotonergic neurontranscription factor

Identifiers

PMID33046550
PMCPMC7643297
OpenAlexW3092590876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.